Rethinking Functional Segregation: Gradients of Gene Expression in Area CA1

被引：5

作者：

Tushev, Georgi ^{[1
,2
]}

Schuman, Erin M. ^{[2
]}

机构：

[1] Max Planck Inst Brain Res, Sci Comp, Max von Laue Str 4, D-60438 Frankfurt, Germany

[2] Max Planck Inst Brain Res, Synapt Plast, Max von Laue Str 4, D-60438 Frankfurt, Germany

来源：

NEURON | 2016年 / 89卷 / 02期

关键词：

VENTRAL HIPPOCAMPUS; PYRAMIDAL NEURONS; RAT; DORSAL; DOMAINS; REGION;

D O I：

10.1016/j.neuron.2016.01.002

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

An emerging view, based on gene expression patterns, is that discrete cell types occupy different regions in the hippocampus. In this issue of Neuron, Cembrowski et al. (2016) challenge this concept by identifying gradients of gene expression that suggest a molecular continuum of excitatory neurons and provide insights for organizational motifs at hippocampal poles.

引用

页码：242 / 243

页数：2

共 13 条

[1] DEVELOPMENT OF THE HIPPOCAMPAL REGION IN THE RAT .1. NEUROGENESIS EXAMINED WITH THYMIDINE-H-3 AUTORADIOGRAPHY [J].

BAYER, SA .

JOURNAL OF COMPARATIVE NEUROLOGY, 1980, 190 (01) :87-114

[2] Spatial Gene-Expression Gradients Underlie Prominent Heterogeneity of CA1 Pyramidal Neurons [J].

Cembrowski, Mark S. ;

Bachman, Julia L. ;

Wang, Lihua ;

Sugino, Ken ;

Shields, Brenda C. ;

Spruston, Nelson .

NEURON, 2016, 89 (02) :351-368

[3] Genomic-anatomic evidence for distinct functional domains in hippocampal field CA1 [J].

Dong, Hong-Wei ;

Swanson, Larry W. ;

Chen, Lin ;

Fanselow, Michael S. ;

Toga, Arthur W. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (28) :11794-11799

[4] Intrinsic excitability of CA1 pyramidal neurones from the rat dorsal and ventral hippocampus [J].

Dougherty, Kelly A. ;

Islam, Tasnim ;

Johnston, Daniel .

JOURNAL OF PHYSIOLOGY-LONDON, 2012, 590 (22) :5707-5722

[5] Are the Dorsal and Ventral Hippocampus Functionally Distinct Structures? [J].

Fanselow, Michael S. ;

Dong, Hong-Wei .

NEURON, 2010, 65 (01) :7-19

[6] Neuronal diversity and temporal dynamics: The unity of hippocampal circuit operations [J].

Klausberger, Thomas ;

Somogyi, Peter .

SCIENCE, 2008, 321 (5885) :53-57

[7] Genome-wide atlas of gene expression in the adult mouse brain [J].

Lein, Ed S. ;

Hawrylycz, Michael J. ;

Ao, Nancy ;

Ayres, Mikael ;

Bensinger, Amy ;

Bernard, Amy ;

Boe, Andrew F. ;

Boguski, Mark S. ;

Brockway, Kevin S. ;

Byrnes, Emi J. ;

Chen, Lin ;

Chen, Li ;

Chen, Tsuey-Ming ;

Chin, Mei Chi ;

Chong, Jimmy ;

Crook, Brian E. ;

Czaplinska, Aneta ;

Dang, Chinh N. ;

Datta, Suvro ;

Dee, Nick R. ;

Desaki, Aimee L. ;

Desta, Tsega ;

Diep, Ellen ;

Dolbeare, Tim A. ;

Donelan, Matthew J. ;

Dong, Hong-Wei ;

Dougherty, Jennifer G. ;

Duncan, Ben J. ;

Ebbert, Amanda J. ;

Eichele, Gregor ;

Estin, Lili K. ;

Faber, Casey ;

Facer, Benjamin A. ;

Fields, Rick ;

Fischer, Shanna R. ;

Fliss, Tim P. ;

Frensley, Cliff ;

Gates, Sabrina N. ;

Glattfelder, Katie J. ;

Halverson, Kevin R. ;

Hart, Matthew R. ;

Hohmann, John G. ;

Howell, Maureen P. ;

Jeung, Darren P. ;

Johnson, Rebecca A. ;

Karr, Patrick T. ;

Kawal, Reena ;

Kidney, Jolene M. ;

Knapik, Rachel H. ;

Kuan, Chihchau L. .

NATURE, 2007, 445 (7124) :168-176

[8] Dorsal-ventral differentiation of short-term synaptic plasticity in rat CA1 hippocampal region [J].

Papatheodoropoulos, C ;

Kostopoulos, G .

NEUROSCIENCE LETTERS, 2000, 286 (01) :57-60

[9] Similar network activity from disparate circuit parameters [J].

Prinz, AA ;

Bucher, D ;

Marder, E .

NATURE NEUROSCIENCE, 2004, 7 (12) :1345-1352

[10] Structural evidence for functional domains in the rat hippocampus [J].

Risold, PY ;

Swanson, LW .

SCIENCE, 1996, 272 (5267) :1484-1486

← 1 2 →