ACTN3:: A genetic influence on muscle function and athletic performance

被引：121
作者：
MacArthur, Daniel G.
North, Kathryn N.
机构：
[1] Childrens Hosp, Inst Neuromuscular Res, Westmead, NSW 2145, Australia
[2] Univ Sydney, Fac Med, Discipline Paediat & Child Hlth, Sydney, NSW 2006, Australia
来源：
EXERCISE AND SPORT SCIENCES REVIEWS | 2007年 / 35卷 / 01期
关键词：
R577X; actinin; genetic association; elite athletes; muscle strength;
D O I：
10.1097/JES.0b013e31802d8874
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
A common variant of the ACTN3 gene, R577X, results in complete deficiency of the alpha-actinin-3 protein in the fast skeletal muscle fibers of more than a billion humans worldwide. We review the evidence that this genetic variant is strongly associated with elite athlete status and with normal variation in human muscle strength and sprinting speed.
引用
收藏
页码：30 / 34
页数：5
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