Pilus Assembly in Gram-Positive Bacteria

被引：9

作者：

Pansegrau, Werner ^{[1
]}

Bagnoli, Fabio ^{[1
]}

机构：

[1] GSK Vaccines, Siena, Italy

来源：

PROTEIN AND SUGAR EXPORT AND ASSEMBLY IN GRAM-POSITIVE BACTERIA | 2017年 / 404卷

关键词：

GROUP-B-STREPTOCOCCUS; INTRAMOLECULAR ISOPEPTIDE BONDS; CELL-WALL; STAPHYLOCOCCUS-AUREUS; CRYSTAL-STRUCTURE; STRUCTURAL BASIS; CORYNEBACTERIUM-DIPHTHERIAE; STABILIZING ISOPEPTIDE; IMMUNOGLOBULIN FOLD; INTERNAL THIOESTER;

D O I：

10.1007/82_2015_5016

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Pili of Gram-positive bacteria are unique structures on the bacterial surface, assembled from covalently linked polypeptide subunits. Pilus assembly proceeds by transpeptidation reactions catalyzed by sortases, followed by covalent anchoring of the filament in the peptidoglycan layer. Another distinctive property is the presence of intramolecular isopeptide bonds, conferring extraordinary chemical and mechanical stability to these elongated structures. Besides their function in cell adhesion and biofilm formation, this section discusses possible application of pilus constituents as vaccine components against Gram-positive pathogens.

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页码：203 / 233

页数：31

相关论文

共 120 条

[1] Pili mediate specific adhesion of Streptococcus pyogenes to human tonsil and skin [J].

Abbot, Emily L. ;

Smith, Wendy D. ;

Siou, Gerard P. S. ;

Chiriboga, Carlos ;

Smith, Rebecca J. ;

Wilson, Janet A. ;

Hirst, Barry H. ;

Kehoe, Michael A. .

CELLULAR MICROBIOLOGY, 2007, 9 (07) :1822-1833

[2] Isopeptide Bonds Block the Mechanical Extension of Pili in Pathogenic Streptococcus pyogenes [J].

Alegre-Cebollada, Jorge ;

Badilla, Carmen L. ;

Fernandez, Julio M. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 285 (15) :11235-11242

[3] Emergence and management of drug-resistant enterococcal infections [J].

Arias, Cesar A. ;

Murray, Barbara E. .

EXPERT REVIEW OF ANTI-INFECTIVE THERAPY, 2008, 6 (05) :637-655

[4] A second pilus type in Streptococcus pneumoniae is prevalent in emerging serotypes and mediates adhesion to host cells [J].

Bagnoli, Fabio ;

Moschioni, Monica ;

Donati, Claudio ;

Dimitrovska, Valentina ;

Ferlenghi, Ilaria ;

Facciotti, Claudia ;

Muzzi, Alessandro ;

Giusti, Fabiola ;

Emolo, Carla ;

Sinisi, Antonella ;

Hilleringmann, Markus ;

Pansegrau, Werner ;

Censini, Stefano ;

Rappuoli, Rino ;

Covacci, Antonello ;

Masignani, Vega ;

Barocchi, Michele A. .

JOURNAL OF BACTERIOLOGY, 2008, 190 (15) :5480-5492

[5] A pneumococcal pilus influences virulence and host inflammatory responses [J].

Barocchi, MA ;

Rie, J ;

Zogaj, X ;

Hemsley, C ;

Albiger, B ;

Kanth, A ;

Dahlberg, S ;

Fernebro, J ;

Moschioni, M ;

Masignani, V ;

Hultenby, K ;

Taddei, AR ;

Beiter, K ;

Wartha, F ;

von Euler, A ;

Covacci, A ;

Holden, DW ;

Normark, S ;

Rappuoli, R ;

Henriques-Normark, B .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (08) :2857-2862

[6] Vaccines in the era of genomics: The pneumococcal challenge [J].

Barocchi, Michele Anne ;

Censini, Stefano ;

Rappuoli, Rino .

VACCINE, 2007, 25 (16) :2963-2973

[7] Toll-like Receptor (TLR) 2 Mediates Inflammatory Responses to Oligomerized RrgA Pneumococcal Pilus Type 1 Protein [J].

Basset, Alan ;

Zhang, Fan ;

Benes, Cyril ;

Sayeed, Sabina ;

Herd, Muriel ;

Thompson, Claudette ;

Golenbock, Douglas T. ;

Camilli, Andrew ;

Malley, Richard .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2013, 288 (04) :2665-2675

[8] The von Willebrand factor A3 domain does not contain a metal ion-dependent adhesion site motif [J].

Bienkowska, J ;

Cruz, M ;

Atiemo, A ;

Handin, R ;

Liddington, R .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (40) :25162-25167

[9] Molecular features of the sortase enzyme family [J].

Bradshaw, William J. ;

Davies, Abigail H. ;

Chambers, Christopher J. ;

Roberts, April K. ;

Shone, Clifford C. ;

Acharya, K. Ravi .

FEBS JOURNAL, 2015, 282 (11) :2097-2114

[10] Use of Lactococcus lactis expressing pili from group B Streptococcus as a broad-coverage vaccine against streptococcal disease [J].

Buccato, Scilla ;

Maione, Domenico ;

Rinaudo, Cira Daniela ;

Volpini, Gianfranco ;

Taddei, Anna Rita ;

Rosini, Roberto ;

Telford, John L. ;

Grandi, Guido ;

Margarit, Immaculada .

JOURNAL OF INFECTIOUS DISEASES, 2006, 194 (03) :331-340

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