Role of vitamin E in preventing acute mercury toxicity in rat

We have examined the effect of both pre- and post-treatment of vitamin E on mercury induced acute toxicity in rats. Mercury (12 mu mol/kg b.w., single intraperitoneal injection) resulted in oxidative injury and metallothionein mRNA expression together with alterations in tissue histology and accumulation of mercury in the body organs. The ameliorating potential of vitamin E (24 mu mol/kg b.w., single intraperitoneal injection) was observed in mercury administered rats. Our findings indicate that vitamin E provides complete protection from mercury toxicity in the liver with both pre- and post-treatments. As mercury is nephrotoxic and neurotoxic, it is interesting to note that post-treatment of vitamin E showed more protection in the kidney compared to pre-treatment. In brain tissue, partial protection was observed on oxidative stress parameters. Our results thus suggest that post-treatment with vitamin E could be more beneficial than pre- treatment in mercury intoxication. (C) 2009 Elsevier B.V. All rights reserved.