DEAD-Box RNA Binding Protein DDX5: Not a Black-Box during Reprogramming

被引：5
作者：
Nefzger, Christian M. [1 ,2 ,3 ]
Polo, Jose M. [1 ,2 ,3 ]
机构：
[1] Monash Univ, Dept Anat & Dev Biol, Wellington Rd, Clayton, Vic 3800, Australia
[2] Monash Biomed Discovery Inst, Dev & Stem Cells Program, Wellington Rd, Clayton, Vic 3800, Australia
[3] Monash Univ, Australian Regenerat Med Inst, Wellington Rd, Clayton, Vic 3800, Australia
来源：
CELL STEM CELL | 2017年 / 20卷 / 04期
关键词：
RYBP;
D O I：
10.1016/j.stem.2017.03.006
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
The role of RNA binding proteins (RBPs) during nuclear reprogramming is poorly characterized. In this issue of Cell Stem Cell, Li et al. (2017) showthat DEAD-box RBP DDX5 acts as a reprogramming roadblock and give important mechanistic insights into the establishment of pluripotency by characterizing the intricate downstream events.
引用
收藏
页码：419 / 420
页数：2
相关论文
共 10 条
  • [1] Mechanisms and models of somatic cell reprogramming
    Buganim, Yosef
    Faddah, Dina A.
    Jaenisch, Rudolf
    [J]. NATURE REVIEWS GENETICS, 2013, 14 (06) : 427 - 439
  • [2] Phases of reprogramming
    David, Laurent
    Polo, Jose M.
    [J]. STEM CELL RESEARCH, 2014, 12 (03) : 754 - 761
  • [3] Transcription factor-mediated reprogramming: epigenetics and therapeutic potential
    Firas, Jaber
    Liu, Xiaodong
    Lim, Sue Mei
    Polo, Jose M.
    [J]. IMMUNOLOGY AND CELL BIOLOGY, 2015, 93 (03) : 284 - 289
  • [4] PCGF Homologs, CBX Proteins, and RYBP Define Functionally Distinct PRC1 Family Complexes
    Gao, Zhonghua
    Zhang, Jin
    Bonasio, Roberto
    Strino, Francesco
    Sawai, Ayana
    Parisi, Fabio
    Kluger, Yuval
    Reinberg, Danny
    [J]. MOLECULAR CELL, 2012, 45 (03) : 344 - 356
  • [5] Guallar Diana, 2014, Front Biol (Beijing), V9, P389
  • [6] Induced Pluripotency and Epigenetic Reprogramming
    Hochedlinger, Konrad
    Jaenisch, Rudolf
    [J]. COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY, 2015, 7 (12):
  • [7] Li HH, 2017, CELL STEM CELL, V20, P462, DOI 10.1016/j.stem.2016.12.002
  • [8] Kdm2b promotes induced pluripotent stem cell generation by facilitating gene activation early in reprogramming
    Liang, Gaoyang
    He, Jin
    Zhang, Yi
    [J]. NATURE CELL BIOLOGY, 2012, 14 (05) : 457 - U45
  • [9] Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
    Takahashi, Kazutoshi
    Yamanaka, Shinya
    [J]. CELL, 2006, 126 (04) : 663 - 676
  • [10] Induced pluripotent stem cell lines derived from human somatic cells
    Yu, Junying
    Vodyanik, Maxim A.
    Smuga-Otto, Kim
    Antosiewicz-Bourget, Jessica
    Frane, Jennifer L.
    Tian, Shulan
    Nie, Jeff
    Jonsdottir, Gudrun A.
    Ruotti, Victor
    Stewart, Ron
    Slukvin, Igor I.
    Thomson, James A.
    [J]. SCIENCE, 2007, 318 (5858) : 1917 - 1920
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