Expedient Iron-Catalyzed C-H Allylation/ Alkylation by Triazole Assistance with Ample Scope

被引：156

作者：

Cera, Gianpiero ^{[1
]}

Haven, Tobias ^{[1
]}

Ackermann, Lutz ^{[1
]}

机构：

[1] Univ Gottingen, Inst Organ & Biomol Chem, Tammannstr 2, D-37077 Gottingen, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2016年 / 55卷 / 04期

基金：

欧洲研究理事会;

关键词：

alkylation; allylation; C-H activation; iron; triazoles; LATE-STAGE DIVERSIFICATION; CARBON-CARBON BONDS; COUPLING REACTIONS; ARYLATION; CARBOXAMIDES; HYDROGEN; FUNCTIONALIZATION; ACTIVATION; C(SP(2))-H; ARENES;

D O I：

10.1002/anie.201509603

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Triazole assistance set the stage for a unified strategy for the iron-catalyzed C-H allylation of arenes, heteroarenes, and alkenes with ample scope. The versatile catalyst also proved competent for site-selective methylation, benzylation, and alkylation with challenging primary and secondary halides. Triazole-assisted C-H activation proceeded chemo-, site-, and diastereo-selectively, and the modular TAM directing group was readily removed in a traceless fashion under exceedingly mild reaction conditions.

引用

页码：1484 / 1488

页数：5

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