Expedient Iron-Catalyzed C-H Allylation/ Alkylation by Triazole Assistance with Ample Scope

被引：156
|
作者：
Cera, Gianpiero [1 ]
Haven, Tobias [1 ]
Ackermann, Lutz [1 ]
机构：
[1] Univ Gottingen, Inst Organ & Biomol Chem, Tammannstr 2, D-37077 Gottingen, Germany
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2016年 / 55卷 / 04期
基金：
欧洲研究理事会;
关键词：
alkylation; allylation; C-H activation; iron; triazoles; LATE-STAGE DIVERSIFICATION; CARBON-CARBON BONDS; COUPLING REACTIONS; ARYLATION; CARBOXAMIDES; HYDROGEN; FUNCTIONALIZATION; ACTIVATION; C(SP(2))-H; ARENES;
D O I：
10.1002/anie.201509603
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Triazole assistance set the stage for a unified strategy for the iron-catalyzed C-H allylation of arenes, heteroarenes, and alkenes with ample scope. The versatile catalyst also proved competent for site-selective methylation, benzylation, and alkylation with challenging primary and secondary halides. Triazole-assisted C-H activation proceeded chemo-, site-, and diastereo-selectively, and the modular TAM directing group was readily removed in a traceless fashion under exceedingly mild reaction conditions.
引用
收藏
页码：1484 / 1488
页数：5
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