The importance of virion-incorporated cellular RNA-Binding Proteins in viral particle assembly and infectivity

被引：14

作者：

Dicker, Kate ^{[1
]}

Jarvelin, Aino I. ^{[1
]}

Garcia-Moreno, Manuel ^{[1
]}

Castello, Alfredo ^{[1
,2
]}

机构：

[1] Univ Oxford, Dept Biochem, South Parks Rd, Oxford OX1 3QU, England

[2] Univ Glasgow, MRC, Ctr Virus Res, 464 Bearsden Rd, Glasgow G61 1QH, Lanark, Scotland

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2021年 / 111卷

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

RNA-binding protein; Virus; Protein-RNA interaction; Virus infection; Virus assembly; Virus replication; RBP; IMMUNODEFICIENCY-VIRUS TYPE-1; REVERSE TRANSCRIPTION; PROTEOMIC ANALYSIS; RIBONUCLEOPROTEIN COMPLEX; MASS-SPECTROMETRY; HOST PROTEINS; GENOMIC RNA; NUCLEAR-PORE; ANNEXIN A2; HIV-1; RNA;

D O I：

10.1016/j.semcdb.2020.08.002

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

RNA is a central molecule in RNA virus biology due to its dual function as messenger and genome. However, the small number of proteins encoded by viral genomes is insufficient to enable virus infection. Hence, viruses hijack cellular RNA-binding proteins (RBPs) to aid replication and spread. In this review we discuss the `known' and `unknowns' regarding the contribution of host RBPs to the formation of viral particles and the initial steps of infection in the newly infected cell. Through comparison of the virion proteomes of ten different human RNA viruses, we confirm that a pool of cellular RBPs are typically incorporated into viral particles. We describe here illustrative examples supporting the important functions of these RBPs in viral particle formation and infectivity and we propose that the role of host RBPs in these steps can be broader than previously anticipated. Understanding how cellular RBPs regulate virus infection can lead to the discovery of novel therapeutic targets against viruses.

引用

页码：108 / 118

页数：11

共 160 条

[31] N6-Methyladenosine and Viral Infection [J].