SOCS1 hypermethylation increases TNF-α induced apoptosis in a human hepatoma cell line

被引:0
作者
Yeganeh, Mehdi [1 ]
Ramanathan, Sheela [1 ]
Leblanc, Chantal [1 ]
Ilangumaran, Subburaj [1 ]
机构
[1] Univ Sherbrooke, CHU Sherbrooke, Dept Pediat, Div Immunol,Ctr Rech Clin Etienne Le Bel, Sherbrooke, PQ J1K 2R1, Canada
关键词
D O I
10.1016/j.cyto.2009.07.160
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
引用
收藏
页码:54 / 54
页数:1
相关论文
共 4 条
[1]   SOCS-1 suppresses TNF-α-induced apoptosis through the regulation of Jak activation [J].
Kimura, A ;
Naka, T ;
Nagata, S ;
Kawase, I ;
Kishimoto, T .
INTERNATIONAL IMMUNOLOGY, 2004, 16 (07) :991-999
[2]   Hepatocyte necrosis induced by oxidative stress and IL-1α release mediate carcinogen-induced compensatory proliferation and liver tumorigenesis [J].
Sakurai, Toshiharu ;
He, Guobin ;
Matsuzawa, Atsushi ;
Yu, Guann-Yi ;
Maeda, Shin ;
Hardiman, Gary ;
Karin, Michael .
CANCER CELL, 2008, 14 (02) :156-165
[3]   Suppressor of cytokine signaling 1 protects mice against concanavalin A-induced hepatitis by inhibiting apoptosis [J].
Torisu, Takehiro ;
Nakaya, Mako ;
Watanabe, Satoko ;
Hashimoto, Masayuki ;
Yoshida, Hideyuki ;
Chinen, Takatoshi ;
Yoshida, Ryoko ;
Okamoto, Fuyuki ;
Hanada, Toshikatsu ;
Torisu, Kumiko ;
Takaesu, Giichi ;
Kobayashi, Takashi ;
Yasukawa, Hideo ;
Yoshimura, Akihiko .
HEPATOLOGY, 2008, 47 (05) :1644-1654
[4]   SOCS-1, a negative regulator of the JAK/STAT pathway, is silenced by methylation in human hepatocellular carcinoma and shows growth-suppression activity [J].
Hirohide Yoshikawa ;
Kenichi Matsubara ;
Geng-Sun Qian ;
Peta Jackson ;
John D. Groopman ;
Jasper E. Manning ;
Curtis C. Harris ;
James G. Herman .
Nature Genetics, 2001, 28 (1) :29-35