Reprogramming of human exocrine pancreas cells to beta cells

被引：5

作者：

Staels, Willem ^{[1
,2
,3
]}

Heremans, Yves ^{[1
]}

Heimberg, Harry ^{[1
]}

机构：

[1] Vrije Univ Brussel, Diabet Res Ctr, B-1090 Brussels, Belgium

[2] Ghent Univ Hosp, Dept Pediat, Div Pediat Endocrinol, Ghent, Belgium

[3] Univ Ghent, Dept Pediat & Genet, B-9000 Ghent, Belgium

来源：

BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM | 2015年 / 29卷 / 06期

关键词：

diabetes; pancreas; beta cell; reprogramming; transdifferentiation; IN-VITRO EXPANSION; ACINAR-CELLS; DUCTAL CELLS; STEM-CELLS; TRANSCRIPTION FACTORS; EXTRACELLULAR-MATRIX; EPIGENETIC MEMORY; MOUSE FIBROBLASTS; ALPHA CELLS; CONVERSION;

D O I：

10.1016/j.beem.2015.10.001

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

One of the key promises of regenerative medicine is providing a cure for diabetes. Cell-based therapies are proving their safety and efficiency, but donor beta cell shortages and immunological issues remain major hurdles. Reprogramming of human pancreatic exocrine cells towards beta cells would offer a major advantage by providing an abundant and autologous source of beta cells. Over the past decade our understanding of transdifferentiation processes greatly increased allowing us to design reprogramming protocols that fairly aim for clinical trials. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：849 / 857

页数：9

共 50 条

[41] Generation of beta cells from human pluripotent stem cells: Potential for regenerative medicine
Nostro, Maria Cristina
Keller, Gordon
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2012, 23 (06) : 701 - 710
[42] Making β Cells from Adult Cells Within the Pancreas
Lysy, Philippe A.
Weir, Gordon C.
Bonner-Weir, Susan
CURRENT DIABETES REPORTS, 2013, 13 (05) : 695 - 703
[43] Are there any stem cells in the pancreas?
Yalniz, M
Pour, PM
PANCREAS, 2005, 31 (02) : 108 - 118
[44] Origin of exocrine pancreatic cells from nestin-positive precursors in developing mouse pancreas
Esni, F
Stoffers, DA
Takeuchi, T
Leach, SD
MECHANISMS OF DEVELOPMENT, 2004, 121 (01) : 15 - 25
[45] Regenerating β cells of the pancreas - potential developments in diabetes treatment
Dong, Shengli
Wu, Hongju
EXPERT OPINION ON BIOLOGICAL THERAPY, 2018, 18 (02) : 175 - 185
[46] Chemical reprogramming of human somatic cells to pluripotent stem cells
Guan, Jingyang
Wang, Guan
Wang, Jinlin
Zhang, Zhengyuan
Fu, Yao
Cheng, Lin
Meng, Gaofan
Lyu, Yulin
Zhu, Jialiang
Li, Yanqin
Wang, Yanglu
Liuyang, Shijia
Liu, Bei
Yang, Zirun
He, Huanjing
Zhong, Xinxing
Chen, Qijing
Zhang, Xu
Sun, Shicheng
Lai, Weifeng
Shi, Yan
Liu, Lulu
Wang, Lipeng
Li, Cheng
Lu, Shichun
Deng, Hongkui
NATURE, 2022, 605 (7909) : 325 - +
[47] Reprogramming of Human Pancreatic Organoid Cells into Insulin-Producing β-Like Cells by Small Molecules and in Vitro Transcribed Modified mRNA Encoding Neurogenin 3 Transcription Factor
Koblas, T.
Leontovyc, I
Loukotova, S.
Saudek, F.
FOLIA BIOLOGICA, 2019, 65 (03) : 109 - 123
[48] In-depth analysis of proteomic and genomic fluctuations during the time course of human embryonic stem cells directed differentiation into beta cells
Budnik, Bogdan
Straubhaar, Juerg
Neveu, John
Shvartsman, Dmitry
PROTEOMICS, 2022, 22 (09)
[49] Reprogramming of Pancreatic Exocrine Cells AR42J Into Insulin-producing Cells Using mRNAs for Pdx1, Ngn3, and MafA Transcription Factors
Koblas, Tomas
Leontovyc, Ivan
Loukotova, Sarka
Kosinova, Lucie
Saudek, Frantisek
MOLECULAR THERAPY-NUCLEIC ACIDS, 2016, 5 : e320
[50] Characterization of the Human Pancreas Side Population as a Potential Reservoir of Adult Stem Cells
Augstein, Petra
Loudovaris, Thomas
Bandala-Sanchez, Esther
Heinke, Peter
Naselli, Gaetano
Lee, Lily
Hawthorne, Wayne J.
Gonez, L. Jorge
Neale, Alana M.
Vaillant, Francois
Thomas, Helen E.
Kay, Thomas W.
Banakh, Ilia
Harrison, Leonard C.
PANCREAS, 2018, 47 (01) : 25 - 34

← 1 2 3 4 5 →