Reprogramming of human exocrine pancreas cells to beta cells

被引：5
作者：
Staels, Willem [1 ,2 ,3 ]
Heremans, Yves [1 ]
Heimberg, Harry [1 ]
机构：
[1] Vrije Univ Brussel, Diabet Res Ctr, B-1090 Brussels, Belgium
[2] Ghent Univ Hosp, Dept Pediat, Div Pediat Endocrinol, Ghent, Belgium
[3] Univ Ghent, Dept Pediat & Genet, B-9000 Ghent, Belgium
来源：
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM | 2015年 / 29卷 / 06期
关键词：
diabetes; pancreas; beta cell; reprogramming; transdifferentiation; IN-VITRO EXPANSION; ACINAR-CELLS; DUCTAL CELLS; STEM-CELLS; TRANSCRIPTION FACTORS; EXTRACELLULAR-MATRIX; EPIGENETIC MEMORY; MOUSE FIBROBLASTS; ALPHA CELLS; CONVERSION;
D O I：
10.1016/j.beem.2015.10.001
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
One of the key promises of regenerative medicine is providing a cure for diabetes. Cell-based therapies are proving their safety and efficiency, but donor beta cell shortages and immunological issues remain major hurdles. Reprogramming of human pancreatic exocrine cells towards beta cells would offer a major advantage by providing an abundant and autologous source of beta cells. Over the past decade our understanding of transdifferentiation processes greatly increased allowing us to design reprogramming protocols that fairly aim for clinical trials. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码：849 / 857
页数：9
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