COPPER-BASED GLASS-CERAMIC AS AN EFFICIENT CATALYST IN THE SYNTHESIS OF PYRAZOLO[1,5-a]PYRIMIDINEUNDER SOLVENT-FREE CONDITION WITH DOCKING VALIDATION AS COVID-19 MAIN PROTEASE (MPRO) INHIBITOR

被引：15

作者：

Abdelghany, Amr M. ^{[1
]}

Khatab, Tamer K. ^{[2
]}

Hassan, Ashraf S. ^{[2
]}

机构：

[1] Natl Res Ctr, Spect Dept, Phys Div, 33 El Behouth St, Cairo 12622, Egypt

[2] Natl Res Ctr, Organometall & Organometalloid Chem Dept, Cairo 12622, Egypt

来源：

BULLETIN OF THE CHEMICAL SOCIETY OF ETHIOPIA | 2021年 / 35卷 / 01期

关键词：

Pyrazolopyrimidine; Enaminones; Copper-based catalysis; Solvent-free; COVID-19; ONE-POT; CYTOTOXIC ACTIVITY; MOLECULAR DOCKING; DERIVATIVES; TETRACHLOROSILANE; REAGENT; DESIGN;

D O I：

10.4314/bcse.v35i1.16

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Copper-based oxide glass-ceramic was successfully synthesized through the single-step melt annealing technique. Synthesized glass-ceramics was characterized using X-ray diffraction (XRD) and scanning electron microscopy (SEM) supported with energy dispersive X-ray (EDX) and mapping. Pyrazolo[1,5-a]pyrimidines 5a-f were synthesized via the reaction of 5-amino-1H-pyrazole-4-carboxamide (1) with enaminones 2a-f in the presence of synthesized oxide glass-ceramic catalyst powder under solvent-free condition. The molecular docking study demonstrated that the COVID-19 main protease (M-Pro) inhibitor.

引用

页码：185 / 196

页数：12

共 44 条

[1]

Abd El-All AS, 2016, ACTA POL PHARM, V73, P79

[2] Pulsed laser ablated zeolite nanoparticles: A novel nano-catalyst for the synthesis of 1,8-dioxo-octahydroxanthene and N-aryl-1,8-dioxodecahydroacridine with molecular docking validation [J].

Abdelghany, A. M. ;

Menazea, A. A. ;

Abd-El-Maksoud, Mansoura A. ;

Khatab, Tamer K. .

APPLIED ORGANOMETALLIC CHEMISTRY, 2020, 34 (02)

[3]

Al Wasidi A. S., 2020, J. Appl. Pharm. Sci., V10, P142, DOI [10.7324/JAPS.2020.104018, DOI 10.7324/JAPS.2020.104018, 10.22207/JPAM.14.1.25, DOI 10.22207/JPAM.14.1.25]

[4] Synthesis and in-vitro anti-proliferative evaluation of some pyrazolo [1,5-a]pyrimidines as novel larotrectinib analogs [J].

Attia, Mohamed H. ;

Elrazaz, Eman Z. ;

El-Emam, Soad Z. ;

Taher, Azza T. ;

Abdel-Aziz, Hatem A. ;

Abouzid, Khaled A. M. .

BIOORGANIC CHEMISTRY, 2020, 94

[5] Tetrachlorosilane-Zinc Chloride as a New Potent Binary Reagent for One-Pot, Three-Component Synthesis of Mannich-Type Products [J].

Badawy, Doria S. ;

Abdel-Galil, Ebrahim ;

Kandeel, Ezzat M. ;

Basyouni, Wahid M. ;

Khatab, Tamer K. .

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 2009, 184 (11) :2799-2812

[6] Design, Synthesis and Antitumor Evaluation of Novel Pyrazolopyrimidines and Pyrazoloquinazolines [J].

El-Naggar, Mohamed ;

Hassan, Ashraf S. ;

Awad, Hanem M. ;

Mady, Mohamed F. .

MOLECULES, 2018, 23 (06)

[7] Evaluation of TCS/ZnCl2 with acetic anhydride as an acetylating reagent for methylene ketones [J].

Elmorsy, SS ;

Badawy, DS ;

Khatab, TK .

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 2005, 180 (01) :109-116

[8]

Elsherif Mervat A., 2020, Journal of Applied Pharmaceutical Science, V10, P37, DOI 10.7324/JAPS.2020.102006

[9] Synthesis, antimicrobial evaluation, molecular docking and theoretical calculations of novel pyrazolo[1,5-a]pyrimidine derivatives [J].

Fahim, Asmaa M. ;

Farag, Ahmad M. .

JOURNAL OF MOLECULAR STRUCTURE, 2020, 1199

[10]

Hassan AS, 2015, EGYPT J CHEM, V58, P113

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