COPPER-BASED GLASS-CERAMIC AS AN EFFICIENT CATALYST IN THE SYNTHESIS OF PYRAZOLO[1,5-a]PYRIMIDINEUNDER SOLVENT-FREE CONDITION WITH DOCKING VALIDATION AS COVID-19 MAIN PROTEASE (MPRO) INHIBITOR

被引：15

作者：

Abdelghany, Amr M. ^{[1
]}

Khatab, Tamer K. ^{[2
]}

Hassan, Ashraf S. ^{[2
]}

机构：

[1] Natl Res Ctr, Spect Dept, Phys Div, 33 El Behouth St, Cairo 12622, Egypt

[2] Natl Res Ctr, Organometall & Organometalloid Chem Dept, Cairo 12622, Egypt

来源：

BULLETIN OF THE CHEMICAL SOCIETY OF ETHIOPIA | 2021年 / 35卷 / 01期

关键词：

Pyrazolopyrimidine; Enaminones; Copper-based catalysis; Solvent-free; COVID-19; ONE-POT; CYTOTOXIC ACTIVITY; MOLECULAR DOCKING; DERIVATIVES; TETRACHLOROSILANE; REAGENT; DESIGN;

D O I：

10.4314/bcse.v35i1.16

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Copper-based oxide glass-ceramic was successfully synthesized through the single-step melt annealing technique. Synthesized glass-ceramics was characterized using X-ray diffraction (XRD) and scanning electron microscopy (SEM) supported with energy dispersive X-ray (EDX) and mapping. Pyrazolo[1,5-a]pyrimidines 5a-f were synthesized via the reaction of 5-amino-1H-pyrazole-4-carboxamide (1) with enaminones 2a-f in the presence of synthesized oxide glass-ceramic catalyst powder under solvent-free condition. The molecular docking study demonstrated that the COVID-19 main protease (M-Pro) inhibitor.

引用

页码：185 / 196

页数：12