Palladium-catalyzed decarboxylative aminocarbonylation with alkynoic acid and tertiary amine for the synthesis of alkynyl amide

被引：11

作者：

Idris, Muhammad Aliyu ^{[1
]}

Kim, Myungjin ^{[1
]}

Kim, Jeung Gon ^{[2
,3
]}

Lee, Sunwoo ^{[1
]}

机构：

[1] Chonnam Natl Univ, Dept Chem, Gwangju 61186, South Korea

[2] Chonbuk Natl Univ, Dept Chem, Jeonju 54896, South Korea

[3] Chonbuk Natl Univ, Res Inst Phys & Chem, Jeonju 54896, South Korea

来源：

TETRAHEDRON | 2019年 / 75卷 / 31期

关键词：

Alkynyl amide; Carbonylation; Tertiary amine; Decarboxylative coupling; Propiolic acids; N BOND ACTIVATION; ONE-POT SYNTHESIS; CARBOXYLIC-ACIDS; COUPLING REACTIONS; TERMINAL ALKYNES; PROPIOLIC ACID; OXIDATIVE AMINOCARBONYLATION; UNSYMMETRICAL DIARYLALKYNES; DEALKYLATIVE CARBONYLATION; ARYL CHLORIDES;

D O I：

10.1016/j.tet.2019.04.030

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We developed a method for the synthesis of alkynyl amides via the carbonylation of alkynoic acids and CN activation of tertiary amines. The reaction of alkynoic acid and tertiary amine with carbon monoxide using a palladium catalyst in the presence of oxygen, KI, and K3PO4, gave the desired alkynyl amides in good yields. (C) 2019 Elsevier Ltd. All rights reserved.

引用

页码：4130 / 4137

页数：8

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