Development of a pressure nociceptive threshold testing device for evaluation of analgesics in cats

被引：45

作者：

Dixon, M. J. ^{[1
]}

Taylor, P. M. ^{[1
]}

Steagall, P. V. M. ^{[1
]}

Brondani, J. T. ^{[1
]}

Luna, S. P. L. ^{[1
]}

机构：

[1] Univ Estadual Paulista Julio Mesquita Filho, FMVZ, Fac Vet Med & Anim Sci, Botucatu, SP, Brazil

来源：

RESEARCH IN VETERINARY SCIENCE | 2007年 / 82卷 / 01期

关键词：

pressure threshold; cat; analgesia; pain; equipment; measurement; pressure nociceptive threshold testing; opioid; NSAID;

D O I：

10.1016/j.rvsc.2006.03.010

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

A pressure analgesiometric device was developed for unrestrained cats. Eleven cats were studied. Stimulation was via three rounded pins within a bracelet on the forearm. The pins were advanced by manual bladder inflation. Bladder pressure was measured using a strain gauge pressure transducer. The threshold was recorded at the behavioural end point. Thresholds were measured at 5 and 15 min intervals for 2-4 h, after removal/replacement of the cuff, for 120 min after SC butorphanol (0.4 mg/kg), and with mild skin inflammation at the testing site. Data were analysed using ANOVA. Pressure thresholds in untreated cats were around 150 mmHg. The minimum interval for testing was established as 15 min. Data were reproducible over 4 h and beyond 24 h. Thresholds in 5 cats increased (P < 0.05) above baseline for 45 min after butorphanol with a maximum increase of 270 +/- 182 mmHg at 10 min. Thresholds decreased with inflammation. The method appears suitable for feline analgesia investigations. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：85 / 92

页数：8

共 31 条

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