Neurodevelopmental Outcomes after Premedication with Atropine/Propofol vs Atropine/Atracurium/Sufentanil for Neonatal Intubation: 2-Year Follow-Up of a Randomized Clinical Trial

被引：6

作者：

Tauzin, Manon ^{[1
]}

Marchand-Martin, Laetitia ^{[2
]}

Lebeaux, Cecile ^{[3
]}

Breinig, Sophie ^{[4
]}

Claris, Olivier ^{[5
]}

Tourneux, Pierre ^{[6
]}

Alexandre, Ceneric ^{[7
]}

Levy, Corinne ^{[8
,9
,10
]}

Jung, Camille ^{[10
]}

Dechartres, Agnes ^{[11
]}

Durrmeyer, Xavier ^{[1
,2
,12
]}

机构：

[1] CHI Creteil, Neonatal Intens Care Unit, Creteil, France

[2] Univ Paris, INRA, INSERM, CRESS, F-75004 Paris, France

[3] CHI Creteil, Reseau Perinatal Val Marne, Creteil, France

[4] CHU Toulouse, Pediat & Neonatal Intens Care Unit, Toulouse, France

[5] Hosp Civils Lyon, Neonatal Intens Care Unit, Lyon, France

[6] CHU Amiens, Neonatal Intens Care Unit, Amiens, France

[7] CHU Caen, Neonatal Intens Care Unit, Caen, France

[8] ACTIV, Creteil, France

[9] Univ Paris Est, IMRB GRC GEMINI, Creteil, France

[10] CHI Creteil, Clin Res Ctr, Creteil, France

[11] Sorbonne Univ, Hop Pitie Salpetriere, AP HP,Dept Sante Publ, INSERM,Inst Pierre Louis Epidemiol & Sante Publ, Paris, France

[12] Univ Paris Est Creteil, Fac Med Creteil, GRC CARMAS, IMRB, Creteil, France

来源：

JOURNAL OF PEDIATRICS | 2021年 / 231卷

关键词：

ages and stages questionnaire; anesthesia; neurodevelopment; neurotoxicity; newborn; pain;

D O I：

10.1016/j.jpeds.2020.12.001

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

This study followed 173 newborn infants in the PREmedication Trial for Tracheal Intubation of the NEOnate multicenter, double-blind, randomized controlled trial of atropine-propofol vs atropine-atracurium-sufentanil for premedication before nonemergency intubation. At 2 years of corrected age, there was no significant difference between the groups in death or risk of neurodevelopmental delay assessed with the Ages and Stages Questionnaire.

引用

页码：273 / +

页数：8

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