Hepatocyte nuclear factor 1 beta: A perspective in cancer

被引：29

作者：

Chandra, Shubhra ^{[1
,2
,3
]}

Srinivasan, Srilakshmi ^{[1
,2
,3
]}

Batra, Jyotsna ^{[1
,2
,3
]}

机构：

[1] Queensland Univ Technol, Australian Prostate Canc Res Ctr Queensland, Inst Hlth & Biomed Innovat, Brisbane, Qld, Australia

[2] Queensland Univ Technol, Australian Prostate Canc Res Ctr Queensland, Sch Biomed Sci, Brisbane, Qld, Australia

[3] Translat Res Inst, Woolloongabba, Qld, Australia

来源：

CANCER MEDICINE | 2021年 / 10卷 / 05期

基金：

英国医学研究理事会;

关键词：

cancer; hepatocyte nuclear factor 1beta; splice variants; transcription factor;

D O I：

10.1002/cam4.3676

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Hepatocyte nuclear factor 1 beta (HNF1 beta/B) exists as a homeobox transcription factor having a vital role in the embryonic development of organs mainly liver, kidney and pancreas. Initially described as a gene causing maturity-onset diabetes of the young (MODY), HNF1 beta expression deregulation and single nucleotide polymorphisms in HNF1 beta have now been associated with several tumours including endometrial, prostate, ovarian, hepatocellular, renal and colorectal cancers. Its function has been studied either as homodimer or heterodimer with HNF1 alpha. In this review, the role of HNF1B in different cancers will be discussed along with the role of its splice variants, and its emerging role as a potential biomarker in cancer.

引用

页码：1791 / 1804

页数：14

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