Down-Regulation of Phosphoribosyl Pyrophosphate Synthetase 1 Inhibits Neuroblastoma Cell Proliferation

被引：14
|
作者：
Li, Jifu [1 ]
Ye, Junhong [1 ,2 ]
Zhu, Shunqin [1 ,3 ]
Cui, Hongjuan [1 ,4 ,5 ,6 ]
机构：
[1] Southwest Univ, Coll Biotechnol, State Key Lab Silkworm Genome Biol, Chongqing 400715, Peoples R China
[2] Southwest Univ, Biol Sci Res Ctr, Chongqing 400715, Peoples R China
[3] Southwest Univ, Sch Life Sci, Chongqing 400715, Peoples R China
[4] Southwest Univ, Engn Res Ctr Canc Biomed & Translat Med, Chongqing 400715, Peoples R China
[5] Southwest Univ, Chongqing Engn & Technol Res Ctr Silk Biomat & Re, Chongqing 400715, Peoples R China
[6] Southwest Univ, Med Res Inst, Canc Ctr, Chongqing, Peoples R China
来源：
CELLS | 2019年 / 8卷 / 09期
关键词：
phosphoribosyl pyrophosphate synthetase 1 (PRPS1); neuroblastoma; cell proliferation; PENTOSE-PHOSPHATE PATHWAY; MYC GENE AMPLIFICATION; OF-FUNCTION MUTATIONS; N-MYC; PRPS1; TUMOR; EXPRESSION; TUMORIGENICITY; PHENOTYPES; APOPTOSIS;
D O I：
10.3390/cells8090955
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Phosphoribosyl pyrophosphate synthetase 1 (PRPS1) is a key enzyme in de novo nucleotide synthesis and nucleotide salvage synthesis pathways that are critical for purine and pyrimidine biosynthesis. Abnormally high expression of PRPS1 can cause many diseases, including hearing loss, hypotonia, and ataxia, in addition to being associated with neuroblastoma. However, the role of PRPS1 in neuroblastoma is still unclear. In this study, we found that PRPS1 was commonly expressed in neuroblastoma cells and was closely related to poor prognosis for cancer. Furthermore, down-regulation of PRPS1 inhibited neuroblastoma cell proliferation and tumor growth in vitro and in vivo via disturbing DNA synthesis. This study provides new insights into the treatment of neuroblastoma patients and new targets for drug development.
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页数：19
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