Subthalamic nucleus gamma activity increases not only during movement but also during movement inhibition

被引：44

作者：

Fischer, Petra ^{[1
,2
]}

Pogosyan, Alek ^{[1
,2
]}

Herz, Damian M. ^{[1
,2
]}

Cheeran, Binith ^{[2
]}

Green, Alexander L. ^{[2
]}

Fitzgerald, James ^{[2
]}

Aziz, Tipu Z. ^{[2
]}

Hyam, Jonathan ^{[3
]}

Little, Simon ^{[3
]}

Foltynie, Thomas ^{[3
]}

Limousin, Patricia ^{[3
]}

Zrinzo, Ludvic ^{[3
]}

Brown, Peter ^{[1
,2
]}

Tan, Huiling ^{[1
,2
]}

机构：

[1] Univ Oxford, Med Res Council Brain Network Dynam Unit, Oxford, England

[2] Univ Oxford, John Radcliffe Hosp, Nuffield Dept Clin Neurosci, Oxford, England

[3] UCL, Inst Neurol, Sobell Dept Motor Neurosci & Movement Disorders, Unit Funct Neurosurg, London, England

来源：

ELIFE | 2017年 / 6卷

基金：

英国惠康基金; 欧盟地平线“2020”; 英国医学研究理事会;

关键词：

INFERIOR FRONTAL GYRUS; RESPONSE-INHIBITION; BASAL-GANGLIA; PARKINSONS-DISEASE; STOP-SIGNAL; OSCILLATORY ACTIVITIES; MOTOR CORTEX; BETA; SYNCHRONIZATION; DOPAMINE;

D O I：

10.7554/eLife.23947

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Gamma activity in the subthalamic nucleus (STN) is widely viewed as a pro-kinetic rhythm. Here we test the hypothesis that rather than being specifically linked to movement execution, gamma activity reflects dynamic processing in this nucleus. We investigated the role of gamma during fast stopping and recorded scalp electroencephalogram and local field potentials from deep brain stimulation electrodes in 9 Parkinson's disease patients. Patients interrupted finger tapping (paced by a metronome) in response to a stop-signal sound, which was timed such that successful stopping would occur only in similar to 50% of all trials. STN gamma (60-90 Hz) increased most strongly when the tap was successfully stopped, whereas phase-based connectivity between the contralateral STN and motor cortex decreased. Beta or theta power seemed less directly related to stopping. In summary, STN gamma activity may support flexible motor control as it did not only increase during movement execution but also during rapid action-stopping.

引用

页数：21

共 65 条

[1] The subthalamic nucleus is involved in successful inhibition in the stop-signal task: A local field potential study in Parkinson's disease [J].