Role of sestrin2 in peroxide signaling in macrophages

被引：84

作者：

Essler, Silke ^{[1
]}

Dehne, Nathalie ^{[1
]}

Bruene, Bernhard ^{[1
]}

机构：

[1] Goethe Univ Frankfurt, Fac Med, D-60590 Frankfurt, Germany

来源：

FEBS LETTERS | 2009年 / 583卷 / 21期

关键词：

Macrophage; Hypoxia-inducible factor; Peroxide signaling; Peroxiredoxin; Sestrin; NITRIC-OXIDE; GENE-EXPRESSION; PEROXIREDOXINS; CELLS; REGENERATION; ACTIVATION; STRESS; NRF2;

D O I：

10.1016/j.febslet.2009.10.017

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Reactive oxygen species not only serve as signaling molecules, they also contribute to oxidative stress and cell damage. The thioredoxin and glutaredoxin systems form along with a precisely regulated defense system to maintain the cellular redox homeostasis. There is evidence that nitric oxide (NO) protects cells from oxidative stress by preventing inactivation of peroxiredoxins by sulfinylation. Here we demonstrate that NO and hypoxia upregulate Sestrin2 by HIF-1-dependent and additional mechanisms and that Sestrin2 contributes to preventing peroxiredoxins from sulfinylation. We conclude that Sestrin2 plays a role in peroxide defense as a reductase for peroxiredoxins. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

引用

页码：3531 / 3535

页数：5

共 24 条

[1] The interplay between nitric oxide and peroxiredoxins [J].

Abbas, Kahina ;

Breton, Jacques ;

Drapier, Jean-Claude .

IMMUNOBIOLOGY, 2008, 213 (9-10) :815-822

[2] The role of antioxidant supplement in immune system, neoplastic, and neurodegenerative disorders: a point of view for an assessment of the risk/benefit profile [J].

Brambilla, Daria ;

Mancuso, Cesare ;

Scuderi, Mariagrazia Rita ;

Bosco, Paolo ;

Cantarella, Giuseppina ;

Lempereur, Laurence ;

Di Benedetto, Giulia ;

Pezzino, Salvatore ;

Bernardini, Renato .

NUTRITION JOURNAL, 2008, 7 (1)

[3] Nitric oxide and superoxide:: Interference with hypoxic signaling [J].

Bruene, Bernhard ;

Zhou, Jie .

CARDIOVASCULAR RESEARCH, 2007, 75 (02) :275-282

[4] Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD [J].

Budanov, AV ;

Sablina, AA ;

Feinstein, E ;

Koonin, EV ;

Chumakov, PM .

SCIENCE, 2004, 304 (5670) :596-600

[5] Identification of a novel stress-responsive gene Hi95 involved in regulation of cell viability [J].

Budanov, AV ;

Shoshani, T ;

Faerman, A ;

Zelin, E ;

Kamer, I ;

Kalinski, H ;

Gorodin, S ;

Fishman, A ;

Chajut, A ;

Einat, P ;

Skaliter, R ;

Gudkov, AV ;

Chumakov, PM ;

Feinstein, E .

ONCOGENE, 2002, 21 (39) :6017-6031

[6] Regeneration of peroxiredoxins during recovery after oxidative stress - Only some overoxidized peroxiredoxins can be reduced during recovery after oxidative stress [J].

Chevallet, M ;

Wagner, E ;

Luche, S ;

van Dorsselaer, A ;

Leize-Wagner, E ;

Rabilloud, T .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (39) :37146-37153

[7] Regulation of PDGF signalling and vascular remodelling by peroxiredoxin II [J].

Choi, MH ;

Lee, IK ;

Kim, GW ;

Kim, BU ;

Han, YH ;

Yu, DY ;

Park, HS ;

Kim, KY ;

Lee, JS ;

Choi, CH ;

Bae, YS ;

Lee, BI ;

Rhee, SG ;

Kang, SW .

NATURE, 2005, 435 (7040) :347-353

[8] HIF-1α is essential for myeloid cell-mediated inflammation [J].

Cramer, T ;

Yamanishi, Y ;

Clausen, BE ;

Förster, I ;

Pawlinski, R ;

Mackman, N ;

Haase, VH ;

Jaenisch, R ;

Corr, M ;

Nizet, V ;

Firestein, GS ;

Gerber, HP ;

Ferrara, N ;

Johnson, RS .

CELL, 2003, 112 (05) :645-657

[9] Thiol oxidation of cell signaling proteins: Controlling an apoptotic equilibrium [J].

Cross, JV ;

Templeton, DJ .

JOURNAL OF CELLULAR BIOCHEMISTRY, 2004, 93 (01) :104-111

[10] HIF-1 in the inflammatory microenvironment [J].

Dehne, Nathalie ;

Bruene, Bernhard .

EXPERIMENTAL CELL RESEARCH, 2009, 315 (11) :1791-1797

← 1 2 3 →