Metabolism of Amino Acids in Cancer

被引：281

作者：

Wei, Zhen ^{[1
]}

Liu, Xiaoyi ^{[2
]}

Cheng, Chunming ^{[3
,4
]}

Yu, Wei ^{[5
]}

Yi, Ping ^{[2
]}

机构：

[1] Wuhan Univ Sci & Technol, Hubei Prov Key Lab Occupat Hazard Identificat & C, Sch Med, Brain Sci & Adv Technol Inst, Wuhan, Peoples R China

[2] Chongqing Med Univ, Dept Obstet & Gynecol, Affiliated Hosp 3, Chongqing, Peoples R China

[3] Ohio State Univ, Dept Radiat Oncol, James Comprehens Canc Ctr, Columbus, OH 43210 USA

[4] Ohio State Univ, Coll Med, Columbus, OH 43210 USA

[5] Fudan Univ, Sch Life Sci, Zhongshan Hosp, State Key Lab Genet Engn, Shanghai, Peoples R China

来源：

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2021年 / 8卷

基金：

中国国家自然科学基金;

关键词：

amino acids (AAs); metabolism; cancer; mTORC (mammalian target of rapamycin kinase complex); epigenetic; tumor immunity; ferroptosis; tumor growth; ONE-CARBON METABOLISM; TRANSPORTER; LAT1; ARGININOSUCCINATE SYNTHETASE EXPRESSION; TRANSFER-RNA SYNTHETASE; GLUTAMINE-METABOLISM; SERINE BIOSYNTHESIS; CELL-DEATH; ARGININE DEIMINASE; DNA METHYLATION; INDOLEAMINE 2,3-DIOXYGENASE;

D O I：

10.3389/fcell.2020.603837

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Metabolic reprogramming has been widely recognized as a hallmark of malignancy. The uptake and metabolism of amino acids are aberrantly upregulated in many cancers that display addiction to particular amino acids. Amino acids facilitate the survival and proliferation of cancer cells under genotoxic, oxidative, and nutritional stress. Thus, targeting amino acid metabolism is becoming a potential therapeutic strategy for cancer patients. In this review, we will systematically summarize the recent progress of amino acid metabolism in malignancy and discuss their interconnection with mammalian target of rapamycin complex 1 (mTORC1) signaling, epigenetic modification, tumor growth and immunity, and ferroptosis. Finally, we will highlight the potential therapeutic applications.

引用

页数：23

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