Synthesis of 1-benzyl-4-[(5,[11C]6-dimethoxy-1-oxoindan-2-yl)methyl]piperidine:: a promising ligand for visualisation of acetylcholine esterase by PET

被引：0
作者：
De Vos, F
Santens, P
Slegers, G
Vermeirsch, H
Dierckx, RA
De Reuck, J
机构：
[1] State Univ Ghent, Dept Radiopharm, B-9000 Ghent, Belgium
[2] State Univ Ghent Hosp, Dept Neurol, B-9000 Ghent, Belgium
[3] State Univ Ghent, Dept Morphol, B-9820 Merelbeke, Belgium
[4] State Univ Ghent Hosp, Dept Nucl Med, B-9000 Ghent, Belgium
来源：
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 2000年 / 43卷 / 06期
关键词：
C-11; synthesis; acetylcholine esterase; PET; donepezil;
D O I：
10.1002/(SICI)1099-1344(200005)43:6<595::AID-JLCR344>3.0.CO;2-B
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Donepezil (1-benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-yl)methyl-]piperidine), a potent acetylcholine esterase inhibitor, was labelled with [C-11]iodomethane by O-methylation of the O-6'-desmethyl precursor. Synthesis, purification and formulation were performed in approximately 30 min with an average specific activity of 39.5 GBq/mu mol at EOS. The total activity available for applications was 7.5-11.1 GBq.
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页码：595 / 601
页数：7
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