Molecular Studies of HTLV-1 Replication: An Update

被引：42

作者：

Martin, Jessica L. ^{[1
,2
]}

Maldonado, Jose O. ^{[3
,4
]}

Mueller, Joachim D. ^{[3
,5
]}

Zhang, Wei ^{[6
]}

Mansky, Louis M. ^{[7
,8
]}

机构：

[1] Univ Minnesota, Inst Mol Virol, Pharmacoimmunol Training Program, 18-242 Moos Tower,515 Delaware St SE, Minneapolis, MN 55455 USA

[2] Univ Minnesota, Inst Mol Virol, Pharmacol Grad Program, 18-242 Moos Tower,515 Delaware St SE, Minneapolis, MN 55455 USA

[3] Univ Minnesota, Inst Mol Virol, 18-242 Moos Tower,515 Delaware St SE, Minneapolis, MN 55455 USA

[4] Univ Minnesota, DDS PhD Dual Degree Program, 18-242 Moos Tower,515 Delaware St SE, Minneapolis, MN 55455 USA

[5] Univ Minnesota, Sch Phys & Astron, 18-242 Moos Tower,515 Delaware St SE, Minneapolis, MN 55455 USA

[6] Univ Minnesota, Inst Mol Virol, Sch Dent & Characterizat Facil, 18-242 Moos Tower,515 Delaware St SE, Minneapolis, MN 55455 USA

[7] Univ Minnesota, Inst Mol Virol, Sch Dent, 18-242 Moos Tower,515 Delaware St SE, Minneapolis, MN 55455 USA

[8] Univ Minnesota, Pharmacol Grad Program, 18-242 Moos Tower,515 Delaware St SE, Minneapolis, MN 55455 USA

来源：

VIRUSES-BASEL | 2016年 / 8卷 / 02期

基金：

美国国家卫生研究院;

关键词：

deltaretrovirus; antiretroviral; lentivirus; T-CELL-LEUKEMIA; VIRUS TYPE-I; NF-KAPPA-B; GLUCOSE-TRANSPORTER GLUT-1; DEPENDENT DNA-POLYMERASE; ELEMENT-BINDING PROTEIN; BLOOD MONONUCLEAR-CELLS; TYPE-1 TAX ONCOPROTEIN; LYMPHOTROPIC-VIRUS; MESSENGER-RNA;

D O I：

10.3390/v8020031

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Human T-cell leukemia virus type 1 (HTLV-1) was the first human retrovirus discovered. Studies on HTLV-1 have been instrumental for our understanding of the molecular pathology of virus-induced cancers. HTLV-1 is the etiological agent of an adult T-cell leukemia (ATL) and can lead to a variety of neurological pathologies, including HTLV-1-associated-myelopathy/tropical spastic paraparesis (HAM/TSP). The ability to treat the aggressive ATL subtypes remains inadequate. HTLV-1 replicates by (1) an infectious cycle involving virus budding and infection of new permissive target cells and (2) mitotic division of cells harboring an integrated provirus. Virus replication initiates host antiviral immunity and the checkpoint control of cell proliferation, but HTLV-1 has evolved elegant strategies to counteract these host defense mechanisms to allow for virus persistence. The study of the molecular biology of HTLV-1 replication has provided crucial information for understanding HTLV-1 replication as well as aspects of viral replication that are shared between HTLV-1 and human immunodeficiency virus type 1 (HIV-1). Here in this review, we discuss the various stages of the virus replication cycleboth foundational knowledge as well as current updates of ongoing research that is important for understanding HTLV-1 molecular pathogenesis as well as in developing novel therapeutic strategies.

引用

页数：22

共 192 条

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