A Comparative Study on Outcome of Holmium Laser Enucleation of Prostateand Transurethral Resection of Prostate in Prostatic Hyperplasia

Objective: Tocomparet hefrequencyofhematuria and meanlength ofstay as outcome of holmium laser enucleationofprostate (HoLEP) and transurethral resectionof prostate (TURP) group with benign prostatic hyperplasia. Methodology: Study was randomizedtrial, conductedin Urologydepartment of General hospital, Lahore,for Six months. Sampling techniquewas consecutive. Those whowerewilling,randomly allocated in twogroups by using lottery method. In Group A, patients undergone HoLEP andin Group B,TURP. Aftersurgery, irrigationstarted withnormal saline solution.Irrigation time wasnoted. Patients wereshifted inward and followedfor next 24 hours. If bloodwas present inrurine grossly, then hemnaturia was labeled. Clinically and vitally stable patients were discharged from wards and hospital staytwasalso noted.Data was collected onpreformedPerformaandanalyzedonSPSS. Results: Total 108 patients fulfilling the inclusion criteria participated. Main outcome variables in this studywerefrequency ofhematuria andlength ofstay(LOS)in hospitalof patients inboth treatment groups. Statistical significance was calculated using two-tailed test. As per findings of this study it was seen that patients frequency of hematuria was significantly higher in patients who were treated with TURP (HoLEP: 3.7% vs. TURP: 29.6%, p-value=0.000) while LOS in hospital was also significantly higher for patients who were treated with TURP (HoLEP: 41.65+10.63 vs. TURP: 54.02 +/- 10.44, pvalue=0.000). Conclusion: Holmiumnlaser enucleation is better than transurethral resection of prostate in terms of shorter hospital stay and low frequency of hematuria postoperatively. HoLEP can replace TURP but more studies required with long term effects.