Vinyl polymers as non-viral gene delivery carriers: Current status and prospects

被引：61
作者：
Dubruel, Peter [1 ]
Schacht, Etienne [1 ]
机构：
[1] Univ Ghent, Polymer Chem & Biomat Res Grp, B-9000 Ghent, Belgium
来源：
MACROMOLECULAR BIOSCIENCE | 2006年 / 6卷 / 10期
关键词：
biological application of polymers; copolymerization; gene delivery; poly(meth)acrylates; polyplexes; vinyl polymers;
D O I：
10.1002/mabi.200600110
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Since the first application of polymers as nonviral gene delivery systems in 1965 by Vaheri and Pagano using functionalised dextran (A. Vaheri and J. S. Pagano, "Infectious poliovirus RNA: a sensitive method of assay", Virology 1965, 27. 434-6), a large number of different polymers have been developed, studied and compared for application as DNA carriers. Vinyl-based polymers are one type of polymers that have gained considerable interest. The interest in developing this particular type of polymer is partly related to the straightforward way in which large amounts of these polymers can be prepared by radical (co)polymerisation. This opens up a path for establishing a wide range of structure-property relations using polymer libraries. The present review aims to give an overview of past and ongoing research using vinyl-based gene delivery systems. The application of cationic, neutral and zwitterionic polymers as DNA carriers is summarised and discussed.
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收藏
页码：789 / 810
页数：22
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