The battle between host and SARS-CoV-2: Innate immunity and viral evasion strategies

被引：44

作者：

Zhang, Shilei ^{[1
]}

Wang, Lulan ^{[1
]}

Cheng, Genhong ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Dept Microbiol Immunol & Mol Genet, Los Angeles, CA 90095 USA

来源：

MOLECULAR THERAPY | 2022年 / 30卷 / 05期

关键词：

PATTERN-RECOGNITION RECEPTORS; NF-KAPPA-B; COMPLEMENT ACTIVATION; CRYSTAL-STRUCTURE; LECTIN RECEPTORS; DC-SIGN; INTERFERON; VIRUS; RNA; CORONAVIRUS;

D O I：

10.1016/j.ymthe.2022.02.014

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The SARS-CoV-2 virus, the pathogen causing COVID-19, has caused more than 200 million confirmed cases, resulting in more than 4.5 million deaths worldwide by the end of August, 2021. Upon detection of SARS-CoV-2 infection by pattern recognition receptors (PRRs), multiple signaling cascades are activated, which ultimately leads to innate immune response such as induction of type I and III interferons, as well as other antiviral genes that together restrict viral spread by suppressing different steps of the viral life cycle. Our understanding of the contribution of the innate immune system in recognizing and subsequently initiating a host response to an invasion of SARS-CoV-2 has been rapidly expanding from 2020. Simultaneously, SARSCoV-2 has evolved multiple immune evasion strategies to escape from host immune surveillance for successful replication. In this review, we will address the current knowledge of innate immunity in the context of SARS-CoV-2 infection and highlight recent advances in the understanding of the mechanisms by which SARS-CoV-2 evades a host's innate defense system.

引用

页码：1869 / 1884

页数：16

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