The Georgia Cardiovascular Twin Study: Influence of genetic predisposition and chronic stress on risk for cardiovascular disease and type 2 diabetes

被引：6

作者：

Ge, Dongliang

Dong, Yanbin

Wang, Xiaoling

Treiber, Frank A.

Snieder, Harold

机构：

[1] Med Coll Georgia, Georgia Prevent Inst, Dept Pediat, Augusta, GA 30912 USA

[2] Kings Coll London, Twin Res & Genet Epidemiol Unit, London WC2R 2LS, England

来源：

TWIN RESEARCH AND HUMAN GENETICS | 2006年 / 9卷 / 06期

关键词：

D O I：

10.1375/183242706779462877

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The Georgia Cardiovascular Twin Study is a longitudinal study of biobehavioral antecedents of cardiovascular disease in youth and young adults, including around 500 twin pairs with roughly equal numbers of African Americans and European Americans. Focus of study includes the longitudinal change in relative influence of genetic and environmental factors (especially chronic stress) on development of risk factors for cardiovascular disease. Approaches include quantitative genetic modeling of phenotypic twin data as well as the examination of the influence of polymorphic variation in candidate genes and their potential interaction with environmental factors on these risk factors. Future work will expand the scope of the study to investigating the impact of chronic stress as measured by indices of the hypothalamus-pituitary-adrenal axis and the sympathetic nervous system on preclinical markers of cardiovascular disease, essential hypertension and type 2 diabetes.

引用

页码：965 / 970

页数：6

共 41 条

[1] ASSESSMENT OF ARTERIAL DISTENSIBILITY BY AUTOMATIC PULSE-WAVE VELOCITY-MEASUREMENT - VALIDATION AND CLINICAL-APPLICATION STUDIES [J].

ASMAR, R ;

BENETOS, A ;

TOPOUCHIAN, J ;

LAURENT, P ;

PANNIER, B ;

BRISAC, AM ;

TARGET, R ;

LEVY, BI .

HYPERTENSION, 1995, 26 (03) :485-490

[2] Impact of transcendental meditation on ambulatory blood pressure in African-American adolescents [J].

Barnes, VA ;

Treiber, FA ;

Johnson, MH .

AMERICAN JOURNAL OF HYPERTENSION, 2004, 17 (04) :366-369

[3] Impact of Transcendental Meditation® on cardiovascular function at rest and during acute stress in adolescents with high normal blood pressure [J].

Barnes, VA ;

Treiber, FA ;

Davis, H .

JOURNAL OF PSYCHOSOMATIC RESEARCH, 2001, 51 (04) :597-605

[4] Impact of meditation on resting and ambulatory blood pressure and heart rate in youth [J].

Barnes, VA ;

Davis, HC ;

Murzynowski, JB ;

Treiber, FA .

PSYCHOSOMATIC MEDICINE, 2004, 66 (06) :909-914

[5] THE ABILITY OF SEVERAL SHORT-TERM MEASURES OF RR VARIABILITY TO PREDICT MORTALITY AFTER MYOCARDIAL-INFARCTION [J].

BIGGER, JT ;

FLEISS, JL ;

ROLNITZKY, LM ;

STEINMAN, RC .

CIRCULATION, 1993, 88 (03) :927-934

[6] Hypothalamic origin of the metabolic Syndrome X [J].

Björntorp, P ;

Rosmond, R .

THE METABOLIC SYNDROME X: CONVERGENCE OF INSULIN RESISTANCE, GLUCOSE INTOLERANCE, HYPERTENSION, OBESITY, AND DYSLIPIDEMIAS-SEARCHING FOR THE UNDERLYING DEFECTS, 1999, 892 :297-307

[7] GENETIC INFLUENCES ON RESPIRATORY SINUS ARRHYTHMIA ACROSS DIFFERENT TASK CONDITIONS [J].