Reductive Coupling between C-N and C-O Electrophiles

被引：105

作者：

He, Rong-De ^{[1
]}

Li, Chun-Ling ^{[1
]}

Pan, Qiu-Quan ^{[1
]}

Guo, Peng ^{[1
]}

Liu, Xue-Yuan ^{[1
]}

Shu, Xing-Zhong ^{[1
]}

机构：

[1] Lanzhou Univ, Coll Chem & Chem Engn, SKLAOC, 222 South Tianshui Rd, Lanzhou 730000, Gansu, Peoples R China

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2019年 / 141卷 / 32期

基金：

中国国家自然科学基金;

关键词：

CATALYZED CROSS-COUPLINGS; UNACTIVATED ALKYL-HALIDES; ARYL HALIDES; BORONIC ACIDS; OXIDATIVE ADDITION; BENZYLIC AMINES; ORGANIC HALIDES; NICKEL; METAL; BONDS;

D O I：

10.1021/jacs.9b05224

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The cross-electrophile reaction is a promising strategy for C-C bond formation. Recent studies have focused mainly on reactions with organic halides. Here we report a coupling reaction between C-N and C-O electrophiles that demonstrates the possibility of constructing a C-C bond via C-N and C-O cleavage. Several reactions between benzyl/aryl ammonium salts and vinyl/aryl C-O electrophiles have been studied. Preliminary mechanistic studies revealed that the benzyl ammoniums were activated through a radical mechanism.

引用

页码：12481 / 12486

页数：6

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