Reductive Coupling between C-N and C-O Electrophiles

被引：103
|
作者：
He, Rong-De [1 ]
Li, Chun-Ling [1 ]
Pan, Qiu-Quan [1 ]
Guo, Peng [1 ]
Liu, Xue-Yuan [1 ]
Shu, Xing-Zhong [1 ]
机构：
[1] Lanzhou Univ, Coll Chem & Chem Engn, SKLAOC, 222 South Tianshui Rd, Lanzhou 730000, Gansu, Peoples R China
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2019年 / 141卷 / 32期
基金：
中国国家自然科学基金;
关键词：
CATALYZED CROSS-COUPLINGS; UNACTIVATED ALKYL-HALIDES; ARYL HALIDES; BORONIC ACIDS; OXIDATIVE ADDITION; BENZYLIC AMINES; ORGANIC HALIDES; NICKEL; METAL; BONDS;
D O I：
10.1021/jacs.9b05224
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The cross-electrophile reaction is a promising strategy for C-C bond formation. Recent studies have focused mainly on reactions with organic halides. Here we report a coupling reaction between C-N and C-O electrophiles that demonstrates the possibility of constructing a C-C bond via C-N and C-O cleavage. Several reactions between benzyl/aryl ammonium salts and vinyl/aryl C-O electrophiles have been studied. Preliminary mechanistic studies revealed that the benzyl ammoniums were activated through a radical mechanism.
引用
收藏
页码：12481 / 12486
页数：6
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