Can Proliferation Signal Inhibitor-Induced Tregs Really Reflect Transplantation Tolerance in Clinical Solid Organ Transplantation?

被引：3

作者：

Li, Suping ^{[1
,2
]}

Kuang, Anren ^{[1
]}

Huang, Rui ^{[1
]}

机构：

[1] Sichuan Univ, Dept Nucl Med, W China Hosp, Chengdu 610064, Peoples R China

[2] Affiliated Hosp, N Sichuan Med Coll, Dept Nucl Med, Nanchong, Peoples R China

来源：

INTERNATIONAL REVIEWS OF IMMUNOLOGY | 2009年 / 28卷 / 05期

关键词：

transplantation; tolerance; regulatory T cells; proliferation signal inhibitors; REGULATORY T-CELLS; IMMUNOLOGICAL SELF-TOLERANCE; TRANSCRIPTION FACTOR FOXP3; CALCINEURIN INHIBITORS; IMMUNOSUPPRESSIVE DRUGS; RENAL-TRANSPLANTATION; RAPAMYCIN; INDUCTION; RECIPIENTS; SURVIVAL;

D O I：

10.1080/08830180903093788

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Exploring new immunosuppressive strategies inducing donor-specific hyporesponsiveness is a great challenge in transplantation. For this purpose, monitoring the alloimmune response is a critical step to carrying out protolerogenic immunosuppressive protocols. Regulatory T cells (Tregs), known as controlling various immune responses, were found to play an important part in allograft transplant tolerance. It is said that Rapamycin (RAPA), one of the proliferation signal inhibitors (PSIs), could achieve true tolerance through the induction of Tregs in clinical trials. Can PSI-induced Tregs in peripheral blood mononuclear cells (PBMC) really reflect transplantation tolerance in clinical solid organ transplantation?

引用

页码：367 / 375

页数：9

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