Aryl Fluorosulfate Trapped Staudinger Reduction

被引：20

作者：

Ren, Gerui ^{[1
,4
]}

Zheng, Qinheng ^{[1
,2
]}

Wang, Hua ^{[1
,3
]}

机构：

[1] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

[2] Scripps Res Inst, TSRI Grad Program, La Jolla, CA 92037 USA

[3] Scripps Res Inst, Dept Chem Physiol, La Jolla, CA 92037 USA

[4] Zhejiang Gongshang Univ, Sch Food Sci & Biotechnol, Dept Appl Chem, Hangzhou 310035, Zhejiang, Peoples R China

来源：

ORGANIC LETTERS | 2017年 / 19卷 / 07期

关键词：

CLICK CHEMISTRY; LIGATION; BIOCONJUGATION; LEELAMINE; SUFEX; AZIDE;

D O I：

10.1021/acs.orglett.7b00406

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A chemoselective Staudinger reduction/sulfur (VI) fluoride exchange cascade has been developed to join two Chemical segments through, an aryl sulfamate ester (RNH- SO2-OAr)linkage. Aryl fluorosulfate-is exploited in this work as the first tetrahedral electrophilic trap for the in situ generated iminophosphorane. Ten examples using azide-containing compounds are presented.

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收藏

页码：1582 / 1585

页数：4

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