Melanocyte pigmentation stiffens murine cardiac tricuspid valve leaflet

被引：29

作者：

Balani, Kantesh ^{[1
,2
]}

Brito, Flavia C.

Kos, Lidia

Agarwal, Arvind ^{[2
]}

机构：

[1] Indian Inst Technol, Kanpur 208016, Uttar Pradesh, India

[2] Florida Int Univ, Dept Mech & Mat Engn, Nanomech & Nanotribol Lab, Miami, FL 33199 USA

来源：

JOURNAL OF THE ROYAL SOCIETY INTERFACE | 2009年 / 6卷 / 40期

关键词：

melanocytes; storage modulus; pigmentation; nanoindentation; valve; heart; HEART-VALVE; MECHANICAL-PROPERTIES; CELL PHENOTYPE; CARTILAGE; BEHAVIOR; DISEASE; MATRIX; REPAIR;

D O I：

10.1098/rsif.2009.0174

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Pigmentation of murine cardiac tricuspid valve leaflet is associated with melanocyte concentration, which affects its stiffness. Owing to its biological and viscoelastic nature, estimation of the in situ stiffness measurement becomes a challenging task. Therefore, quasi-static and nanodynamic mechanical analysis of the leaflets of the mouse tricuspid valve is performed in the current work. The mechanical properties along the leaflet vary with the degree of pigmentation. Pigmented regions of the valve leaflet that contain melanocytes displayed higher storage modulus (7-10 GPa) than nonpigmented areas (2.5-4 GPa). These results suggest that the presence of melanocytes affects the viscoelastic properties of the mouse atrioventricular valves and are important for their proper functioning in the organism.

引用

页码：1097 / 1102

页数：6

共 34 条

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