Minimized proteins

被引：85
作者：
Cunningham, BC
Wells, JA
机构：
[1] Department of Protein Engineering, Genentech Inc, 460 Point S. Bruno B., San Francisco
来源：
CURRENT OPINION IN STRUCTURAL BIOLOGY | 1997年 / 7卷 / 04期
关键词：
D O I：
10.1016/S0959-440X(97)80107-8
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The design of bioactive small molecules for interaction at larger protein-protein interfaces remains a challenge. Recent progress towards minimizing proteins into significantly smaller polypeptides has been achieved via both rational design processes and selection from vast combinatorial libraries. Such 'mini-proteins' represent a potential intermediate step toward the development of drugs targeted to protein-protein interfaces.
引用
收藏
页码：457 / 462
页数：6
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