Clinical Application of Circulating Tumor Cells in Gastric Cancer

被引:36
作者
Lee, Moon Won [1 ,2 ]
Kim, Gwang Ha [1 ,2 ]
Jeon, Hye Kyung [1 ,2 ]
Park, Su Jin [1 ,2 ]
机构
[1] Pusan Natl Univ, Sch Med, Dept Internal Med, 179 Gudeok Ro, Busan 49241, South Korea
[2] Pusan Natl Univ Hosp, Biomed Res Inst, 179 Gudeok Ro, Busan 49241, South Korea
关键词
Circulating tumor cells; Liquid biopsy; Neoplasms; Stomach neoplasms; EPITHELIAL-MESENCHYMAL TRANSITIONS; TRANSENDOTHELIAL MIGRATION; PROGNOSTIC VALUE; BREAST-CANCER; CARCINOMA; CADHERIN; BLOOD; EXPRESSION; RESISTANCE; SURVIVAL;
D O I
10.5009/gnl18484
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Early detection and accurate monitoring of cancer is important for improving clinical outcomes. Endoscopic biopsy and/or surgical resection specimens are the gold standard for diagnosing gastric cancer and are also useful for selecting therapeutic strategies based on the analysis of genomic/immune parameters. However, these approaches cannot be easily performed because of their invasiveness and because these specimens do not always reflect tumor dynamics and drug sensitivities during therapeutic processes, especially chemotherapy. Accordingly, many researchers have tried to develop noninvasive novel biomarkers that can monitor realtime tumor dynamics for early diagnosis, prognostic evaluation, and prediction of recurrence and therapeutic efficacy. Circulating tumor cells (CTCs) are metastatic cells that are released from the primary tumors into the blood stream and comprise a crucial step in hematogenous metastasis. CTCs, as a liquid biopsy, have received a considerable amount of attention from researchers since they are easily accessible in peripheral blood, avoiding the invasiveness associated with traditional biopsy techniques; they can also be used to derive clinical information for monitoring disease status. In this review, with respect to CTCs, we summarize the metastatic cascade, detection methods, clinical applications, and prospects for patients with gastric cancer.
引用
收藏
页码:394 / 401
页数:8
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