In utero and peripubertal metals exposure in relation to reproductive hormones and sexual maturation and progression among girls in Mexico City
被引:54
作者:
Ashrap, Pahriya
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Univ Michigan, Sch Publ Hlth, Dept Environm Hlth Sci, 1415 Washington Hts, Ann Arbor, MI 48109 USAUniv Michigan, Sch Publ Hlth, Dept Environm Hlth Sci, 1415 Washington Hts, Ann Arbor, MI 48109 USA
Ashrap, Pahriya
[1
]
Sanchez, Brisa N.
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机构:
Univ Michigan, Sch Publ Hlth, Dept Biostat, Ann Arbor, MI 48109 USAUniv Michigan, Sch Publ Hlth, Dept Environm Hlth Sci, 1415 Washington Hts, Ann Arbor, MI 48109 USA
Sanchez, Brisa N.
[2
]
Tellez-Rojo, Martha M.
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h-index: 0
机构:
Inst Nacl Salud Publ, Ctr Nutr & Hlth Res, Cuernavaca, Morelos, MexicoUniv Michigan, Sch Publ Hlth, Dept Environm Hlth Sci, 1415 Washington Hts, Ann Arbor, MI 48109 USA
Tellez-Rojo, Martha M.
[3
]
Basu, Niladri
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机构:
McGill Univ, Fac Agr & Environm Sci, Montreal, PQ, CanadaUniv Michigan, Sch Publ Hlth, Dept Environm Hlth Sci, 1415 Washington Hts, Ann Arbor, MI 48109 USA
Basu, Niladri
[4
]
Tamayo-Ortiz, Marcela
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机构:
Inst Nacl Salud Publ, Ctr Nutr & Hlth Res, Cuernavaca, Morelos, Mexico
Mexican Council Sci & Technol, Mexico City, DF, MexicoUniv Michigan, Sch Publ Hlth, Dept Environm Hlth Sci, 1415 Washington Hts, Ann Arbor, MI 48109 USA
Tamayo-Ortiz, Marcela
[3
,6
]
Peterson, Karen E.
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机构:
Univ Michigan, Sch Publ Hlth, Dept Nutr Sci, Ann Arbor, MI 48109 USAUniv Michigan, Sch Publ Hlth, Dept Environm Hlth Sci, 1415 Washington Hts, Ann Arbor, MI 48109 USA
Peterson, Karen E.
[5
]
Meeker, John D.
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机构:
Univ Michigan, Sch Publ Hlth, Dept Environm Hlth Sci, 1415 Washington Hts, Ann Arbor, MI 48109 USAUniv Michigan, Sch Publ Hlth, Dept Environm Hlth Sci, 1415 Washington Hts, Ann Arbor, MI 48109 USA
Meeker, John D.
[1
]
Watkins, Deborah J.
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Univ Michigan, Sch Publ Hlth, Dept Environm Hlth Sci, 1415 Washington Hts, Ann Arbor, MI 48109 USAUniv Michigan, Sch Publ Hlth, Dept Environm Hlth Sci, 1415 Washington Hts, Ann Arbor, MI 48109 USA
Watkins, Deborah J.
[1
]
机构:
[1] Univ Michigan, Sch Publ Hlth, Dept Environm Hlth Sci, 1415 Washington Hts, Ann Arbor, MI 48109 USA
[2] Univ Michigan, Sch Publ Hlth, Dept Biostat, Ann Arbor, MI 48109 USA
There is increasing evidence that several metals are endocrine disrupting chemicals (EDCs). In utero development and adolescence are critical windows of susceptibility to EDC exposure. With the exception of a few heavy metals, few human studies have evaluated the impact of metal exposure on pubertal development. Our aim was to investigate measures of in utero and peripubertal metal exposure in relation to reproductive hormone levels and sexual maturation and progression among girls from the Early Life Exposure in Mexico to Environmental Toxicants (ELEMENT) cohorts. We measured urinary concentrations of aluminum (Al), arsenic (As), barium (Ba), cadmium (Cd), cobalt (Co), copper (Cu), iron (Fe), manganese (Mn), molybdenum (Mo), nickel (Ni), antimony (Sb), selenium (Se), and zinc (Zn) in samples collected from women during their third trimester of pregnancy and from their female children at 8-13 years (n = 132). We measured serum testosterone, estradiol, dehydroepiandrosterone sulfate (DHEA-S), inhibin B, and sex hormone-binding globulin (SHBG) at age 8-13, and assessed Tanner stages for sexual maturation (breast, pubic hair development, and menarche status), at two time points (8-13, 14-18 years). We used linear regression to independently examine in utero and peripubertal metal concentrations as predictors of peripubertal hormones. In a longitudinal analysis using generalized estimation equations, we evaluated Tanner stage and menarche progression in relation to individual in utero and peripubertal metal concentrations. We found that higher in utero Zn was associated with increased inhibin B. Several metals at 8-13 years were associated with higher DHEA-S and estradiol, while Ni was positively but Cu was negatively associated with testosterone. In utero Ni, Al, and Cd were associated with slower progression of breast development after adjustment for child age and BMI z-score. For example, an IQR increase in in utero Al exposure was associated with 0.82 times lower odds of progressing to a higher Tanner stage for breast development per year (95% CI: 0.68, 0.99). Peripubertal concentrations of Ba and Al were also associated with being at a higher pubic hair Tanner stage and menarche at 8-13, but lower odds of progressing to the next stage at 14-18 years. We used Bayesian kernel machine regression (BKMR) to model the joint effect of multiple metals while accounting for correlated exposures, as well as potential non-linear relationships between metals and outcomes of interest, which yielded results similar to individual analyses. These findings suggest that female reproductive development may be vulnerable to the effects of metal exposure, and using both Tanner stages and hormone levels may provide clues about underlying mechanisms in two sensitive periods of development.
机构:
SUNY Albany, Dept Environm Hlth Sci, Sch Publ Hlth, Rensselaer, NY 12144 USASUNY Albany, Dept Environm Hlth Sci, Sch Publ Hlth, Rensselaer, NY 12144 USA
Bloom, Michael S.
Parsons, Patrick J.
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机构:
New York State Dept Hlth, Lab Inorgan & Nucl Chem, Wadsworth Ctr, Albany, NY USASUNY Albany, Dept Environm Hlth Sci, Sch Publ Hlth, Rensselaer, NY 12144 USA
Parsons, Patrick J.
Steuerwald, Amyl
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h-index: 0
机构:
New York State Dept Hlth, Lab Inorgan & Nucl Chem, Wadsworth Ctr, Albany, NY USASUNY Albany, Dept Environm Hlth Sci, Sch Publ Hlth, Rensselaer, NY 12144 USA
Steuerwald, Amyl
Schisterman, Enrique F.
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h-index: 0
机构:
Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Div Epidemiol Stat & Prevent Res, Rockville, MD USASUNY Albany, Dept Environm Hlth Sci, Sch Publ Hlth, Rensselaer, NY 12144 USA
Schisterman, Enrique F.
Browne, Richard W.
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h-index: 0
机构:
SUNY Buffalo, Dept Biotech & Clin Lab Sci, Buffalo, NY 14260 USASUNY Albany, Dept Environm Hlth Sci, Sch Publ Hlth, Rensselaer, NY 12144 USA
Browne, Richard W.
Kim, Keewan
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h-index: 0
机构:
SUNY Albany, Dept Epidemiol & Biostat, Rensselaer, NY 12144 USASUNY Albany, Dept Environm Hlth Sci, Sch Publ Hlth, Rensselaer, NY 12144 USA
Kim, Keewan
Coccaro, Gregory A.
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h-index: 0
机构:
SUNY Albany, Dept Biomed Sci, Rensselaer, NY 12144 USASUNY Albany, Dept Environm Hlth Sci, Sch Publ Hlth, Rensselaer, NY 12144 USA
Coccaro, Gregory A.
Conti, Giulia C.
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h-index: 0
机构:
Univ Calif San Francisco, Dept Obstet Gynecol & Reprod Sci, San Francisco, CA 94143 USASUNY Albany, Dept Environm Hlth Sci, Sch Publ Hlth, Rensselaer, NY 12144 USA
Conti, Giulia C.
Narayan, Natasha
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Dept Obstet Gynecol & Reprod Sci, San Francisco, CA 94143 USASUNY Albany, Dept Environm Hlth Sci, Sch Publ Hlth, Rensselaer, NY 12144 USA
Narayan, Natasha
Fujimoto, Victor Y.
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机构:
Univ Calif San Francisco, Dept Obstet Gynecol & Reprod Sci, San Francisco, CA 94143 USASUNY Albany, Dept Environm Hlth Sci, Sch Publ Hlth, Rensselaer, NY 12144 USA
机构:
Kaiser Permanente Washington Hlth Res Inst, Biostat Unit, 1730 Minor Ave 1600, Seattle, WA 98101 USA
Univ Washington, Dept Biostat, Seattle, WA 98195 USAKaiser Permanente Washington Hlth Res Inst, Biostat Unit, 1730 Minor Ave 1600, Seattle, WA 98101 USA
Bobb, Jennifer F.
Henn, Birgit Claus
论文数: 0引用数: 0
h-index: 0
机构:
Boston Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA USAKaiser Permanente Washington Hlth Res Inst, Biostat Unit, 1730 Minor Ave 1600, Seattle, WA 98101 USA
Henn, Birgit Claus
Valeri, Linda
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机构:
McLean Hosp, Psychiat Biostat Lab, 115 Mill St, Belmont, MA 02178 USAKaiser Permanente Washington Hlth Res Inst, Biostat Unit, 1730 Minor Ave 1600, Seattle, WA 98101 USA
Valeri, Linda
Coull, Brent A.
论文数: 0引用数: 0
h-index: 0
机构:
Harvard TH Chan Sch Publ Hlth, Dept Biostat, Boston, MA USAKaiser Permanente Washington Hlth Res Inst, Biostat Unit, 1730 Minor Ave 1600, Seattle, WA 98101 USA
机构:
SUNY Albany, Dept Environm Hlth Sci, Sch Publ Hlth, Rensselaer, NY 12144 USASUNY Albany, Dept Environm Hlth Sci, Sch Publ Hlth, Rensselaer, NY 12144 USA
Bloom, Michael S.
Parsons, Patrick J.
论文数: 0引用数: 0
h-index: 0
机构:
New York State Dept Hlth, Lab Inorgan & Nucl Chem, Wadsworth Ctr, Albany, NY USASUNY Albany, Dept Environm Hlth Sci, Sch Publ Hlth, Rensselaer, NY 12144 USA
Parsons, Patrick J.
Steuerwald, Amyl
论文数: 0引用数: 0
h-index: 0
机构:
New York State Dept Hlth, Lab Inorgan & Nucl Chem, Wadsworth Ctr, Albany, NY USASUNY Albany, Dept Environm Hlth Sci, Sch Publ Hlth, Rensselaer, NY 12144 USA
Steuerwald, Amyl
Schisterman, Enrique F.
论文数: 0引用数: 0
h-index: 0
机构:
Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Div Epidemiol Stat & Prevent Res, Rockville, MD USASUNY Albany, Dept Environm Hlth Sci, Sch Publ Hlth, Rensselaer, NY 12144 USA
Schisterman, Enrique F.
Browne, Richard W.
论文数: 0引用数: 0
h-index: 0
机构:
SUNY Buffalo, Dept Biotech & Clin Lab Sci, Buffalo, NY 14260 USASUNY Albany, Dept Environm Hlth Sci, Sch Publ Hlth, Rensselaer, NY 12144 USA
Browne, Richard W.
Kim, Keewan
论文数: 0引用数: 0
h-index: 0
机构:
SUNY Albany, Dept Epidemiol & Biostat, Rensselaer, NY 12144 USASUNY Albany, Dept Environm Hlth Sci, Sch Publ Hlth, Rensselaer, NY 12144 USA
Kim, Keewan
Coccaro, Gregory A.
论文数: 0引用数: 0
h-index: 0
机构:
SUNY Albany, Dept Biomed Sci, Rensselaer, NY 12144 USASUNY Albany, Dept Environm Hlth Sci, Sch Publ Hlth, Rensselaer, NY 12144 USA
Coccaro, Gregory A.
Conti, Giulia C.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Dept Obstet Gynecol & Reprod Sci, San Francisco, CA 94143 USASUNY Albany, Dept Environm Hlth Sci, Sch Publ Hlth, Rensselaer, NY 12144 USA
Conti, Giulia C.
Narayan, Natasha
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Dept Obstet Gynecol & Reprod Sci, San Francisco, CA 94143 USASUNY Albany, Dept Environm Hlth Sci, Sch Publ Hlth, Rensselaer, NY 12144 USA
Narayan, Natasha
Fujimoto, Victor Y.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Dept Obstet Gynecol & Reprod Sci, San Francisco, CA 94143 USASUNY Albany, Dept Environm Hlth Sci, Sch Publ Hlth, Rensselaer, NY 12144 USA
机构:
Kaiser Permanente Washington Hlth Res Inst, Biostat Unit, 1730 Minor Ave 1600, Seattle, WA 98101 USA
Univ Washington, Dept Biostat, Seattle, WA 98195 USAKaiser Permanente Washington Hlth Res Inst, Biostat Unit, 1730 Minor Ave 1600, Seattle, WA 98101 USA
Bobb, Jennifer F.
Henn, Birgit Claus
论文数: 0引用数: 0
h-index: 0
机构:
Boston Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA USAKaiser Permanente Washington Hlth Res Inst, Biostat Unit, 1730 Minor Ave 1600, Seattle, WA 98101 USA
Henn, Birgit Claus
Valeri, Linda
论文数: 0引用数: 0
h-index: 0
机构:
McLean Hosp, Psychiat Biostat Lab, 115 Mill St, Belmont, MA 02178 USAKaiser Permanente Washington Hlth Res Inst, Biostat Unit, 1730 Minor Ave 1600, Seattle, WA 98101 USA
Valeri, Linda
Coull, Brent A.
论文数: 0引用数: 0
h-index: 0
机构:
Harvard TH Chan Sch Publ Hlth, Dept Biostat, Boston, MA USAKaiser Permanente Washington Hlth Res Inst, Biostat Unit, 1730 Minor Ave 1600, Seattle, WA 98101 USA