Synthesis and functionalization of N-sulfinyl imines: Sonogashira reaction and copper-catalyzed azide-alkyne cycloaddition

被引：2
|
作者：
Souza, Frederico B. [1 ]
Vasconcelos, Stanley N. S. [1 ]
Reis, Joel S. [1 ]
Pimenta, Daniel C. [2 ]
Stefani, Helio [1 ]
机构：
[1] Univ Sao Paulo, Fac Ciencias Farmaceut, Dept Farmacia, Sao Paulo, Brazil
[2] Inst Butantan, Sao Paulo, Brazil
来源：
TETRAHEDRON LETTERS | 2017年 / 58卷 / 11期
基金：
巴西圣保罗研究基金会;
关键词：
N-sulfinyl imines; Sonogashira reaction; Heterocycle; Cycloaddition; Triazole; ASYMMETRIC-SYNTHESIS; ORGANIC-SYNTHESIS; LIGANDS; CHEMISTRY; TRIAZOLE;
D O I：
10.1016/j.tetlet.2017.01.107
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A small library of novel molecules was generated using a rapid and efficient methodology for the synthesis of N-sulfinyl imine triazole compounds. The process involves a coupling step from the Sonogashira cross-coupling reaction and then, in a one-step reaction, deprotection of the trimethylsilyl group and triazole heterocyclic ring formation using a microwave reactor. (C) 2017 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1057 / 1060
页数：4
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