Synthesis and functionalization of N-sulfinyl imines: Sonogashira reaction and copper-catalyzed azide-alkyne cycloaddition

被引：2

作者：

Souza, Frederico B. ^{[1
]}

Vasconcelos, Stanley N. S. ^{[1
]}

Reis, Joel S. ^{[1
]}

Pimenta, Daniel C. ^{[2
]}

Stefani, Helio ^{[1
]}

机构：

[1] Univ Sao Paulo, Fac Ciencias Farmaceut, Dept Farmacia, Sao Paulo, Brazil

[2] Inst Butantan, Sao Paulo, Brazil

来源：

TETRAHEDRON LETTERS | 2017年 / 58卷 / 11期

基金：

巴西圣保罗研究基金会;

关键词：

N-sulfinyl imines; Sonogashira reaction; Heterocycle; Cycloaddition; Triazole; ASYMMETRIC-SYNTHESIS; ORGANIC-SYNTHESIS; LIGANDS; CHEMISTRY; TRIAZOLE;

D O I：

10.1016/j.tetlet.2017.01.107

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A small library of novel molecules was generated using a rapid and efficient methodology for the synthesis of N-sulfinyl imine triazole compounds. The process involves a coupling step from the Sonogashira cross-coupling reaction and then, in a one-step reaction, deprotection of the trimethylsilyl group and triazole heterocyclic ring formation using a microwave reactor. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：1057 / 1060

页数：4

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