Chronic gestational cocaine treatment decreases oxytocin levels in the medial preoptic area, ventral tegmental area and hippocampus in Sprague-Dawley rats

被引：45

作者：

Johns, JM ^{[1
]}

Lubin, DA ^{[1
]}

Walker, CH ^{[1
]}

Meter, KE ^{[1
]}

Mason, GA ^{[1
]}

机构：

[1] UNIV N CAROLINA, DEPT PSYCHOL, SCH MED, CHAPEL HILL, NC 27599 USA

来源：

NEUROPEPTIDES | 1997年 / 31卷 / 05期

关键词：

D O I：

10.1016/S0143-4179(97)90037-8

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We examined the effects of gestational cocaine treatment on oxytocin levels in the whole hippocampus (HIP), ventral tegmental area (VTA), medial preoptic area (MPOA) and amygdala (AMY) in rat darns on postpartum days (PPDs) 1 and 2. Cocaine treatment significantly reduced oxytocin levels in the MPOA within 12-16 h of delivery (ppD 1), but had no significant effect on the other brain areas. Oxytocin was significantly reduced in the HIP and VTA but not in the AMY or MPOA on PPD 2. These data provide the first evidence for the reduction of oxytocin levels in the VTA, HIP and MPOA as a result of gestational cocaine treatment.

引用

页码：439 / 443

页数：5

共 37 条

[1]

Bridges R.S., 1990, MAMMALIAN PARENTING, P93

[2] PROLACTIN BRAIN INTERACTIONS IN THE INDUCTION OF MATERNAL-BEHAVIOR IN RATS [J].

BRIDGES, RS ;

MANN, PE .

PSYCHONEUROENDOCRINOLOGY, 1994, 19 (5-7) :611-622

[3] COCAINE EFFECTS IN THE VENTRAL TEGMENTAL AREA - EVIDENCE FOR AN INDIRECT DOPAMINERGIC MECHANISM OF ACTION [J].

BRODIE, MS ;

DUNWIDDIE, TV .

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 1990, 342 (06) :660-665

[4] COCAINE USE IN PREGNANCY [J].

CHASNOFF, IJ ;

BURNS, WJ ;

SCHNOLL, SH ;

BURNS, KA .

NEW ENGLAND JOURNAL OF MEDICINE, 1985, 313 (11) :666-669

[5]

COOPER J, 1996, BIOCH BASIS NEUROPHA

[6]

Fahrbach S. E., 1985, OXYTOCIN CLIN LABORA, P372

[7] POSSIBLE ROLE FOR ENDOGENOUS OXYTOCIN IN ESTROGEN-FACILITATED MATERNAL-BEHAVIOR IN RATS [J].

FAHRBACH, SE ;

MORRELL, JI ;

PFAFF, DW .

NEUROENDOCRINOLOGY, 1985, 40 (06) :526-532

[8] OXYTOCIN INDUCTION OF SHORT-LATENCY MATERNAL-BEHAVIOR IN NULLIPAROUS, ESTROGEN-PRIMED FEMALE RATS [J].

FAHRBACH, SE ;

MORRELL, JI ;

PFAFF, DW .

HORMONES AND BEHAVIOR, 1984, 18 (03) :267-286

[9] OXYTOCIN IN THE AMYGDALA FACILITATES MATERNAL AGGRESSION [J].

FERRIS, CF ;

FOOTE, KB ;

MELTSER, HM ;

PLENBY, MG ;

SMITH, KL ;

INSEL, TR .

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES-SERIES, 1992, 652 :456-457

[10] PHARMACOLOGICAL CHARACTERISTICS AND ANATOMICAL DISTRIBUTION OF [H-3] OXYTOCIN-BINDING SITES IN THE WISTAR RAT-BRAIN STUDIED BY AUTORADIOGRAPHY [J].

FREUNDMERCIER, MJ ;

STOECKEL, ME ;

PALACIOS, JM ;

PAZOS, A ;

REICHHART, JM ;

PORTE, A ;

RICHARD, P .

NEUROSCIENCE, 1987, 20 (02) :599-614

← 1 2 3 4 →