Rostral ventral medulla cholinergic mechanism in pain-induced analgesia

被引：26

作者：

Gear, Robert W. ^{[2
]}

Levine, Jon D. ^{[1
,2
]}

机构：

[1] Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Dept Oral & Maxillofacial Surg, San Francisco, CA 94143 USA

来源：

NEUROSCIENCE LETTERS | 2009年 / 464卷 / 03期

基金：

美国国家卫生研究院;

关键词：

Nucleus accumbens; Noxious stimulation; Antinociception; Pedunculopontine tegmental nucleus; Acetylcholine; PEDUNCULOPONTINE TEGMENTAL NUCLEUS; NICOTINIC ACETYLCHOLINE-RECEPTORS; RAT SPINAL-CORD; RAPHE MAGNUS; NOXIOUS-STIMULATION; BRAIN-STEM; ANTINOCICEPTION; NEURONS; ACCUMBENS; INJECTIONS;

D O I：

10.1016/j.neulet.2009.08.036

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The ascending nociceptive control (ANC), a novel spinostriatal pain modulation pathway. mediates a form of pain-induced analgesia referred to as noxious stimulus-induced antinociception (NSIA). ANC includes specific spinal cord mechanisms as well as circuitry in nucleus accumbens, a major component of the ventral striatum. Here, using the trigeminal jaw-opening reflex (JOR) in the rat as a nociceptive assay, we show that microinjection of the nicotinic acetylcholine receptor (nAChR) antagonist mecamylamine into the rostral ventral medulla (RVM) blocks NSIA, implicating RVM as a potentially important link between ANC and the PAG-RVM-spinal descending pain modulation system. A circuit connecting nucleus accumbens to the RVM is proposed as a novel striato-RVM pathway. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

引用

页码：170 / 172

页数：3

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