Application of mass spectrometry-based proteomics for biomarker discovery in neurological disorders

被引：8

作者：

Venugopal, Abhilash ^{[1
]}

Chaerkady, Raghothama ^{[1
,2
,3
,4
,5
]}

Pandey, Akhilesh ^{[2
,3
,4
,5
]}

机构：

[1] Inst Bioinformat, Bangalore 560066, Karnataka, India

[2] Johns Hopkins Univ, McKusick Nathans Inst Genet Med, Baltimore, MD 21205 USA

[3] Johns Hopkins Univ, Dept Biol Chem, Baltimore, MD 21205 USA

[4] Johns Hopkins Univ, Dept Oncol, Baltimore, MD 21205 USA

[5] Johns Hopkins Univ, Dept Pathol, Baltimore, MD 21205 USA

来源：

ANNALS OF INDIAN ACADEMY OF NEUROLOGY | 2009年 / 12卷 / 01期

关键词：

Biomarkers; diagnosis; isotope labeling; mass spectrometry; HUMAN CEREBROSPINAL-FLUID; ALZHEIMERS-DISEASE; QUANTITATIVE PROTEOMICS; AMINO-ACIDS; PROTEIN BIOMARKERS; POTASSIUM CHANNEL; PLASMA-PROTEOME; IDENTIFICATION; EXPRESSION; SERUM;

D O I：

10.4103/0972-2327.48845

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Mass spectrometry-based quantitative proteomics has emerged as a powerful approach that has the potential to accelerate biomarker discovery, both for diagnostic as well as therapeutic purposes. Proteomics has traditionally been synonymous with 2D gels but is increasingly shifting to the use of gel-free systems and liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS). Quantitative proteomic approaches have already been applied to investigate various neurological disorders, especially in the context of identifying biomarkers from cerebrospinal fluid and serum. This review highlights the scope of different applications of quantitative proteomics in understanding neurological disorders with special emphasis on biomarker discovery.

引用

页码：3 / 11

页数：9

共 62 条

[1] Mass spectrometry-based proteomics [J].

Aebersold, R ;

Mann, M .

NATURE, 2003, 422 (6928) :198-207

[2] NMDA di-heteromeric receptor populations and associated proteins in rat hippocampus [J].

Al-Hallaq, Rana A. ;

Conrads, Thomas P. ;

Veenstra, Timothy D. ;

Wenthold, Robert J. .

JOURNAL OF NEUROSCIENCE, 2007, 27 (31) :8334-8343

[3] Clinical cancer proteomics: Promises and pitfalls [J].

Alaiya, A ;

Al-Mohanna, M ;

Linder, S .

JOURNAL OF PROTEOME RESEARCH, 2005, 4 (04) :1213-1222

[4] The human plasma proteome - History, character, and diagnostic prospects [J].

Anderson, NL ;

Anderson, NG .

MOLECULAR & CELLULAR PROTEOMICS, 2002, 1 (11) :845-867

[5] Discovering robust protein biomarkers for disease from relative expression reversals in 2-D DIGE data [J].

Anderson, Troy J. ;

Tchemyshyov, Irina ;

Diez, Roberto ;

Cole, Robert N. ;

Geman, Donald ;

Dang, Chi V. ;

Winslow, Raimond L. .

PROTEOMICS, 2007, 7 (08) :1197-1207

[6] Synaptic multiprotein complexes associated with 5-HT2C receptors:: a proteomic approach [J].

Bécamel, C ;

Alonso, G ;

Geléotti, N ;

Demey, E ;

Jouin, P ;

Ullmer, C ;

Dumuis, A ;

Bockaert, J ;

Marin, P .

EMBO JOURNAL, 2002, 21 (10) :2332-2342

[7] Incipient Alzheimer's disease: Microarray correlation analyses reveal major transcriptional and tumor suppressor responses [J].

Blalock, EM ;

Geddes, JW ;

Chen, KC ;

Porter, NM ;

Markesbery, WR ;

Landfield, PW .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (07) :2173-2178

[8] Comparative proteomics of cerebrospinal fluid in neuropathologically-confirmed Alzheimer's disease and non-demented elderly subjects [J].

Castaño, EM ;

Roher, AE ;

Esh, CL ;

Kokjohn, TA ;

Beach, T .

NEUROLOGICAL RESEARCH, 2006, 28 (02) :155-163

[9] 8-Plex quantitation of changes in cerebrospinal fluid protein expression in subjects undergoing intravenous immunoglobulin treatment for Alzheimer's disease [J].

Choe, Leila ;

D'Ascenzo, Mark ;

Relkin, Norman R. ;

Pappin, Darryl ;

Ross, Philip ;

Williamson, Brian ;

Guertin, Steven ;

Pribil, Patrick ;

Lee, Kelvin H. .

PROTEOMICS, 2007, 7 (20) :3651-3660

[10] Proteome study of human cerebrospinal fluid following traumatic brain injury indicates fibrin(ogen) degradation products as trauma-associated markers [J].

Conti, A ;

Sanchez-Ruiz, Y ;

Bachi, A ;

Beretta, L ;

Grandi, E ;

Beltramo, M ;

Alessio, M .

JOURNAL OF NEUROTRAUMA, 2004, 21 (07) :854-863

← 1 2 3 4 5 6 7 →