Preparation and in vitro studies of fixed-dose tablet combination of repaglinide and metformin

被引：0
作者：
Sahin, Sinem [1 ]
Mesut, Burcu [2 ]
Durgun, M. Ezgi [2 ]
Ozcelik, Esher [3 ]
Ozsoy, Yildiz [2 ]
机构：
[1] Onko Kocsel Pharmaceut, Kocaeli, Turkey
[2] Istanbul Univ, Fac Pharm, Pharmaceut Technol Dept, Istanbul, Turkey
[3] Cibali Hlth & Social Secur Ctr, Istanbul, Turkey
来源：
ISTANBUL JOURNAL OF PHARMACY | 2021年 / 51卷 / 01期
关键词：
Fixed-Dose Tablet; Metformin; Repaglinide; TYPE-2; PHARMACOKINETICS; THERAPY; CARE;
D O I：
10.26650/IstanbulJPharm.2020.0070
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Background and Aims: The study aimed to design a Fixed-dose tablet formulation of Metformine and Repaglinide. Methods: Wet granulation method was used to prepare tablet formulations. Characterization studies and dissolution studies were performed. Results: A stable formulation was developed according to the requirements of the pharmacopoeia criteria. This new formulsation dissolution results showed that Repaglinide and Metformin HCl dissolved more than 85% from film tablets at 15 minutes. Conclusion: Thus, an alternative product to the market product was developed.
引用
收藏
页码：26 / 34
页数：9
相关论文
共 50 条
[41]   Drug-Drug Interaction Profile of the Fixed-Dose Combination Tablet Regimen Ledipasvir/Sofosbuvir [J].
German, Polina ;
Mathias, Anita ;
Brainard, Diana M. ;
Kearney, Brian P. .
CLINICAL PHARMACOKINETICS, 2018, 57 (11) :1369-1383
[42]   COMPARATIVE BIOAVAILABILITY OF A FIXED-DOSE COMBINATION TABLET OF OLMESARTAN MEDOXOMIL / HYDROCHLOROTHIAZIDE IN HEALTHY KOREAN VOLUNTEERS [J].
Zheng, Renhua ;
Hwang, Ho Min ;
Kim, Bo-Hyung .
ACTA POLONIAE PHARMACEUTICA, 2016, 73 (02) :509-516
[43]   Clinical Pharmacokinetics and Pharmacodynamics of Ledipasvir/Sofosbuvir, a Fixed-Dose Combination Tablet for the Treatment of Hepatitis C [J].
German, Polina ;
Mathias, Anita ;
Brainard, Diana ;
Kearney, Brian P. .
CLINICAL PHARMACOKINETICS, 2016, 55 (11) :1337-1351
[44]   Bioequivalence Evaluation in Healthy Volunteers: New Generic Formulations of Sitagliptin and Sitagliptin-Metformin Fixed-Dose Combination Compared with the Originator Products [J].
Schnaars, Yvonne ;
Gaikwad, Sumedh ;
Gottwald-Hostalek, Ulrike ;
Uhl, Wolfgang ;
Ribot, Olga ;
Varanasi, Kanthikiran V. S. ;
Rodriguez, Laura ;
Torrejon, Javier ;
Gomez, Luis .
DIABETES THERAPY, 2023, 14 (02) :347-362
[45]   Fixed-Dose Combination of Dipeptidyl Peptidase-4 Inhibitors Plus Metformin in Patients with Type 2 Diabetes: A Review on Safety and Efficacy [J].
Alshahrani, Sultan M. ;
Alshahrani, Hamed Ali ;
Alshahrani, Saud Dhafer ;
Alabdulla, Noura Mohammed ;
Alshahrani, Yazeed Fahad ;
Alshahrani, Abdulmohsen Nasser ;
Alshahrani, Ali Mohammed .
JOURNAL OF PHARMACEUTICAL RESEARCH INTERNATIONAL, 2021, 33 (53A) :53-59
[46]   Acarbose plus metformin fixed-dose combination outperforms acarbose monotherapy for type 2 diabetes [J].
Wang, Jun-Sing ;
Huang, Chien-Ning ;
Hung, Yi-Jen ;
Kwok, Ching-Fai ;
Sun, Jui-Hung ;
Pei, Dee ;
Yang, Chwen-Yi ;
Chen, Ching-Chu ;
Lin, Ching-Ling ;
Sheu, Wayne Huey-Herng .
DIABETES RESEARCH AND CLINICAL PRACTICE, 2013, 102 (01) :16-24
[47]   Design of Experiments for Critical Material Attributes Assessment of Linagliptin and Metformin Fixed-dose Combination Tablets [J].
Kim, Kang Min .
INDIAN JOURNAL OF PHARMACEUTICAL EDUCATION AND RESEARCH, 2021, 55 (03) :701-708
[48]   Efficacy of Alogliptin/Metformin Fixed-Dose Combination Tablets and Vildagliptin/Metformin Fixed-Dose Combination Tablets on Glycemic Control in Real-World Clinical Practice for the Patients with Type 2 Diabetes: A Multicenter, Open-Label, Randomized, Parallel Group, Comparative Trial [J].
Abe, Tomoe ;
Takeda, Yasutaka ;
Sakuma, Ichiro ;
Okada, Mizuho ;
Kurigaki, Ayaka ;
Bessho, Ryoichi ;
Sato, Mao ;
Kitsunai, Hiroya ;
Takiyama, Yumi ;
Sakurai, Masaru .
METABOLIC SYNDROME AND RELATED DISORDERS, 2024, 22 (09) :651-660
[49]   Pharmacodynamic effects of voglibose administered alone, administered with metformin, and administered with metformin in a fixed-dose combination in healthy Korean subjects [J].
Kim, Ho-Sook ;
Oh, Minkyung ;
Kim, Eun Ji ;
Song, Geun Seog ;
Kim, Eun-young ;
Shin, Jae-Gook .
INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS, 2018, 56 (11) :544-550
[50]   The effect of pioglitazone as add-on therapy to metformin or sulphonylurea compared to a fixed-dose combination of metformin and glibenclamide on diabetic dyslipidaemia [J].
Comaschi, M. ;
Corsi, A. ;
Di Pietro, C. ;
Bellatreccia, A. ;
Mariz, S. .
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES, 2008, 18 (05) :373-379
12345