Preparation and in vitro studies of fixed-dose tablet combination of repaglinide and metformin

被引：0
作者：
Sahin, Sinem [1 ]
Mesut, Burcu [2 ]
Durgun, M. Ezgi [2 ]
Ozcelik, Esher [3 ]
Ozsoy, Yildiz [2 ]
机构：
[1] Onko Kocsel Pharmaceut, Kocaeli, Turkey
[2] Istanbul Univ, Fac Pharm, Pharmaceut Technol Dept, Istanbul, Turkey
[3] Cibali Hlth & Social Secur Ctr, Istanbul, Turkey
来源：
ISTANBUL JOURNAL OF PHARMACY | 2021年 / 51卷 / 01期
关键词：
Fixed-Dose Tablet; Metformin; Repaglinide; TYPE-2; PHARMACOKINETICS; THERAPY; CARE;
D O I：
10.26650/IstanbulJPharm.2020.0070
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Background and Aims: The study aimed to design a Fixed-dose tablet formulation of Metformine and Repaglinide. Methods: Wet granulation method was used to prepare tablet formulations. Characterization studies and dissolution studies were performed. Results: A stable formulation was developed according to the requirements of the pharmacopoeia criteria. This new formulsation dissolution results showed that Repaglinide and Metformin HCl dissolved more than 85% from film tablets at 15 minutes. Conclusion: Thus, an alternative product to the market product was developed.
引用
收藏
页码：26 / 34
页数：9
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