Association of RUNX3 Methylation with Clinical Outcome and Cell Migration/Invasion in Laryngeal Squamous Cell Carcinoma

被引：6

作者：

Liu, Zhao-hui ^{[1
,2
]}

Liu, Jia-jia ^{[1
]}

Li, Shi-sheng ^{[1
]}

Yang, Xin-ming ^{[1
]}

机构：

[1] Cent S Univ, Xiangya Hosp 2, Dept Otolaryngol Head & Neck Surg, Changsha 410000, Hunan, Peoples R China

[2] Zunyi Med Coll, Affiliated Hosp, Dept Otolaryngol Head & Neck Surg, Zunyi, Guizhou, Peoples R China

来源：

CANCER INVESTIGATION | 2016年 / 34卷 / 02期

关键词：

DNA methylation; Laryngeal squamous cell carcinoma; Runt-related transcription factor; Expression; Cell migration; TRANSFORMING-GROWTH-FACTOR; PROMOTER METHYLATION; CANCER; HYPERMETHYLATION; EXPRESSION; EPIGENETICS; GENES;

D O I：

10.3109/07357907.2015.1104690

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

This study identifies promoter methylation status of RUNX3 in 77 LSCC patient tissues and their paired adjacent healthy tissues. Hypermethylation percentage RUNX3 occurred in LSCC samples was significantly higher than that in normal tissues, as well as associated with suppression of RUNX3 expression, TNM classification of malignant tumors stage, lymph node metastasis and poor overall survival rate. Reduced methylation and increased expression of RUNX3 genes in vitro was observed and decreased cell migration was further confirmed following 5-azacytidine treatment. RUNX 3 promoter hypermethylation can lead to down-regulation of RUNX3 in LSCC cancerous tissue.

引用

页码：105 / 113

页数：9

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