Pro-angiogenic cytokines and their role in tumor angiogenesis

被引：83

作者：

Neufeld, Gera ^{[1
]}

Kessler, Ofra ^{[1
]}

机构：

[1] Technion Israel Inst Technol, Bruce Rappaport Fac Med, Rappaport Res Inst Med Sci, Canc & Vasc Biol Res Ctr, IL-31096 Haifa, Israel

来源：

CANCER AND METASTASIS REVIEWS | 2006年 / 25卷 / 03期

基金：

以色列科学基金会;

关键词：

tumor progression; tumorigenesis; review; angiogenesis; lymphangiogenesis cytokines; metastasis; tumor angiogenesis;

D O I：

10.1007/s10555-006-9011-5

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The development of solid tumors depends upon an adequate supply of blood. This can be achieved by way of co-option of preexisting blood vessels and by the induction of angiogenesis. During the past 30 years, tumor angiogenesis had been found to play a crucial role in the progression of solid tumors. Tumor angiogenesis was found to be induced by a variety of pro-angiogenic cytokines of which the best characterized is vascular endothelial growth factor (VEGF). Indeed, the first FDA approved anti-angiogenic drug for the treatment of cancer is Avastin (TM), a neutralizing antibdy directed against VEGF. This review focuses on cytokines which have been reported to induce tumor angiogenesis.

引用

收藏

页码：373 / 385

页数：13

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