Tackling the Selectivity Dilemma of Benzopyrylium-Coumarin Dyes in Fluorescence Sensing of HClO and SO2

被引：74

作者：

Han, Jinliang ^{[1
]}

Yang, Sheng ^{[1
]}

Wang, Benhua ^{[1
]}

Song, Xiangzhi ^{[1
,2
]}

机构：

[1] Cent South Univ, Coll Chem & Chem Engn, Changsha 410083, Hunan, Peoples R China

[2] Key Lab Hunan Prov Water Environm & Agr Prod Safe, Changsha 410083, Hunan, Peoples R China

来源：

ANALYTICAL CHEMISTRY | 2021年 / 93卷 / 12期

基金：

中国国家自然科学基金;

关键词：

HYPOCHLOROUS-ACID; SULFUR-DIOXIDE; LIVING CELLS; PROBE; DERIVATIVES; WAVELENGTH; FEATURES; STRESS; SHIFT;

D O I：

10.1021/acs.analchem.0c05266

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Benzopyrylium-coumarin fluorescent probes for sensing hypochlorous acid (HClO) or sulfur dioxide (SO2) are unable to distinguish between HClO and SO2 because the two compounds can react with the 4-position of benzopyrylium-coumarin dyes through the nucleophilic attack. In the current work, we introduced a phenoxazine moiety to the benzopyrylium-coumarin dye to synthesize a new fluorescent probe PBC1, which can dually sense HClO and SO2 and generate distinct fluorescence signals with rapid response time and high sensitivity and selectivity. Moreover, probe PBC1 was also successfully utilized to detect intracellular HClO and SO2 in HeLa cells and zebrafish.

引用

页码：5194 / 5200

页数：7

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