Role of T2*Magnetic Resonance in Monitoring Iron Chelation Therapy

被引：21

作者：

Carpenter, John-Paul ^{[1
]}

Pennell, Dudley J. ^{[1
]}

机构：

[1] Royal Brompton Hosp, Cardiovasc Magnet Resonance Unit, London SW3 6NP, England

来源：

ACTA HAEMATOLOGICA | 2009年 / 122卷 / 2-3期

关键词：

Cardiac complications; Chelation; Magnetic resonance imaging; Monitoring of thalassaemia patients; Myocardial siderosis; T2*; Thalassaemia; THALASSEMIA MAJOR PATIENTS; MYOCARDIAL IRON; MAGNETIC-RESONANCE; DEFEROXAMINE; OVERLOAD; HEART; CARDIOMYOPATHY; DEFERIPRONE; DIAGNOSIS; ABILITY;

D O I：

10.1159/000243799

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The monitoring of chelation therapy is a very important part of the management of transfusion-dependent patients. Classical methods of monitoring iron loading are either unreliable or unable to detect important myocardial siderosis which can predispose to the development of cardiac complications such as heart failure. The development of the T2* technique using cardiovascular magnetic resonance has allowed clinicians to have a reliable method for measuring cardiac iron to guide chelation therapy. T2* can identify early those patients who are at risk of developing cardiac complications, enabling personalised, tailored therapy to avoid potential problems. Copyright (C) 2009 S. Karger AG, Basel

引用

页码：146 / 154

页数：9

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