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Enantioselective copper(II)-catalyzed Henry reaction utilizing chiral aziridinyl alcohols
被引:10
|作者:
Wang, Xiaojuan
[1
]
Zhao, Wenxian
[1
,2
]
Li, Gaowei
[1
]
Wang, Jin
[2
]
Liu, Guanjun
[2
]
Liu, Lantao
[1
]
Zhao, Ruijuan
[2
]
Wang, Mincan
[2
]
机构:
[1] Shangqiu Normal Univ, Sch Chem & Chem Engn, Shangqiu 476000, Henan, Peoples R China
[2] Zhengzhou Univ, Coll Chem & Mol Engn, Zhengzhou 450052, Henan, Peoples R China
基金:
中国国家自然科学基金;
关键词:
aziridinyl alcohols;
copper;
asymmetric synthesis;
Henry reaction;
ASYMMETRIC NITROALDOL REACTION;
AMINO-ALCOHOLS;
LIGANDS;
ALDEHYDES;
DIETHYLZINC;
CATALYST;
COMPLEX;
REDUCTION;
DESIGN;
D O I:
10.1002/aoc.3232
中图分类号:
O69 [应用化学];
学科分类号:
081704 ;
摘要:
A family of enantiopure -aminoalcohols based on aziridine backbones were synthesized, and examined as chiral ligands for the copper(II)-catalyzed asymmetric Henry reaction of aromatic aldehydes with nitromethane, giving -nitroalcohols in excellent yields (up to 93%) and moderate to good enantioselectivities (up to 82%). Moreover, possible transition states of the reaction are proposed. Copyright (c) 2014 John Wiley & Sons, Ltd.
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页码:892 / 899
页数:8
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