Enantioselective copper(II)-catalyzed Henry reaction utilizing chiral aziridinyl alcohols

被引：10

作者：

Wang, Xiaojuan ^{[1
]}

Zhao, Wenxian ^{[1
,2
]}

Li, Gaowei ^{[1
]}

Wang, Jin ^{[2
]}

Liu, Guanjun ^{[2
]}

Liu, Lantao ^{[1
]}

Zhao, Ruijuan ^{[2
]}

Wang, Mincan ^{[2
]}

机构：

[1] Shangqiu Normal Univ, Sch Chem & Chem Engn, Shangqiu 476000, Henan, Peoples R China

[2] Zhengzhou Univ, Coll Chem & Mol Engn, Zhengzhou 450052, Henan, Peoples R China

来源：

APPLIED ORGANOMETALLIC CHEMISTRY | 2014年 / 28卷 / 12期

基金：

中国国家自然科学基金;

关键词：

aziridinyl alcohols; copper; asymmetric synthesis; Henry reaction; ASYMMETRIC NITROALDOL REACTION; AMINO-ALCOHOLS; LIGANDS; ALDEHYDES; DIETHYLZINC; CATALYST; COMPLEX; REDUCTION; DESIGN;

D O I：

10.1002/aoc.3232

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A family of enantiopure -aminoalcohols based on aziridine backbones were synthesized, and examined as chiral ligands for the copper(II)-catalyzed asymmetric Henry reaction of aromatic aldehydes with nitromethane, giving -nitroalcohols in excellent yields (up to 93%) and moderate to good enantioselectivities (up to 82%). Moreover, possible transition states of the reaction are proposed. Copyright (c) 2014 John Wiley & Sons, Ltd.

引用

页码：892 / 899

页数：8

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