PET imaging approaches for inflammatory lung diseases: Current concepts and future directions

被引：21

作者：

Chen, Delphine L. ^{[1
,2
]}

Schiebler, Mark L. ^{[3
]}

Goo, Jin Mo ^{[4
]}

van Beek, Edwin J. R. ^{[5
]}

机构：

[1] Mallinckrodt Inst Radiol, Div Radiol Sci, Campus Box 8225,510S,Kingshighway Blvd, St Louis, MO USA

[2] Mallinckrodt Inst Radiol, Div Nucl Med, Campus Box 8225,510S,Kingshighway Blvd, St Louis, MO USA

[3] UW Madison, Sch Med & Publ Heath, Dept Radiol, Madison, WI USA

[4] Seoul Natl Univ, Dept Radiol, Seoul, South Korea

[5] Univ Edinburgh, Queens Med Res Inst, Clin Res Imaging Ctr, Edinburgh, Midlothian, Scotland

来源：

EUROPEAN JOURNAL OF RADIOLOGY | 2017年 / 86卷

基金：

美国国家卫生研究院;

关键词：

Positron emission tomography; COPD; Pulmonary fibrosis; Asthma; (18)Fluorodeoxyglucose; (18)Fluoro-fluciclatide; F-18-NOS; NITRIC-OXIDE SYNTHASE; IDIOPATHIC PULMONARY-FIBROSIS; METABOLIC-ACTIVITY; AIRWAY EPITHELIUM; GLUCOSE-UPTAKE; IN-VIVO; INJURY; EXPRESSION; DISSOCIATION; PATHOGENESIS;

D O I：

10.1016/j.ejrad.2016.09.014

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Inflammatory lung disease is one of the most common clinical scenarios, and yet, it is often poorly understood. Inflammatory lung disorders, such as chronic obstructive pulmonary diseases, which are causing significant mortality and morbidity, have limited therapeutic options. Recently, new treatments have become available for pulmonary fibrosis. This review article will describe the new insights that are starting to be gained from positron emission tomography (PET) methods, by targeting molecular processes using dedicated radiotracers. Ultimately, this should aid in deriving better pathophysiological classification of these disorders, which will ultimately result in better evaluation of novel therapies. (C) 2016 Elsevier Ireland Ltd. All rights reserved.

引用

页码：371 / 376

页数：6

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