Asymptomatic humans transmit dengue virus to mosquitoes

被引：331

作者：

Duong, Veasna ^{[1
]}

Lambrechts, Louis ^{[2
,3
]}

Paul, Richard E. ^{[3
,4
]}

Ly, Sowath ^{[5
]}

Lay, Rath Srey ^{[1
]}

Long, Kanya C. ^{[6
]}

Huy, Rekol ^{[7
]}

Tarantola, Arnaud ^{[5
]}

Scott, Thomas W. ^{[6
,8
]}

Sakuntabhai, Anavaj ^{[3
,4
]}

Buchy, Philippe ^{[1
,9
]}

机构：

[1] Inst Pasteur Cambodia, Int Network Pasteur Inst, Virol Unit, Phnom Penh 12201, Cambodia

[2] Inst Pasteur, Dept Genomes & Genet, Insect Virus Interact Grp, F-75015 Paris, France

[3] CNRS, Unite Rech Associee 3012, F-75015 Paris, France

[4] Inst Pasteur, Dept Genomes & Genet, Funct Genet Infect Dis Unit, F-75015 Paris, France

[5] Inst Pasteur Cambodia, Int Network Pasteur Inst, Epidemiol & Publ Hlth Unit, Phnom Penh 12201, Cambodia

[6] Univ Calif Davis, Dept Entomol & Nematol, Davis, CA 95616 USA

[7] Minist Hlth, Natl Ctr Malariol, Phnom Penh 12302, Cambodia

[8] NIH, Fogarty Int Ctr, Bethesda, MD 20892 USA

[9] GlaxoSmithKline, Vaccines Value Hlth Sci, Singapore 189720, Singapore

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2015年 / 112卷 / 47期

基金：

美国国家卫生研究院;

关键词：

mosquito experimental infection; Cambodia; Aedes aegypti; human-to-mosquito transmission; dengue; DISEASE SEVERITY; AEDES-AEGYPTI; PCR ASSAY; INFECTIONS; INAPPARENT; VIREMIA; DETERMINANTS; OUTBREAK; CHILDREN; THAILAND;

D O I：

10.1073/pnas.1508114112

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Three-quarters of the estimated 390 million dengue virus (DENV) infections each year are clinically inapparent. People with inapparent dengue virus infections are generally considered dead-end hosts for transmission because they do not reach sufficiently high viremia levels to infect mosquitoes. Here, we show that, despite their lower average level of viremia, asymptomatic people can be infectious to mosquitoes. Moreover, at a given level of viremia, DENV-infected people with no detectable symptoms or before the onset of symptoms are significantly more infectious to mosquitoes than people with symptomatic infections. Because DENV viremic people without clinical symptoms may be exposed to more mosquitoes through their undisrupted daily routines than sick people and represent the bulk of DENV infections, our data indicate that they have the potential to contribute significantly more to virus transmission to mosquitoes than previously recognized.

引用

页码：14688 / 14693

页数：6

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