Feasibility study on radiofrequency ablation followed by partial mastectomy for stage I breast cancer patients

被引：36

作者：

Imoto, Shigeru ^{[1
]}

Wada, Noriaki ^{[2
]}

Sakemura, Noriko ^{[1
]}

Hasebe, Takahiro ^{[3
]}

Murata, Yukinori ^{[4
]}

机构：

[1] Kyorin Univ, Sch Med, Dept Breast Surg, Tokyo 1818611, Japan

[2] Natl Canc Ctr Hosp E, Div Breast Surg, Chiba 2778577, Japan

[3] Natl Canc Ctr, Ctr Canc Control & Informat Serv, Clin Trials & Practice Support Div, Off Pathol Consultat Serv, Tokyo 1040045, Japan

[4] Kohnodai Hosp, Int Med Ctr Japan, Pathol Sect, Clin Lab Div, Chiba 2728516, Japan

来源：

BREAST | 2009年 / 18卷 / 02期

关键词：

Breast cancer; Radiofrequency ablation; Breast-conserving surgery; Intraductal components; CARCINOMA; CHEMOTHERAPY; TRIAL; NODES;

D O I：

10.1016/j.breast.2009.02.008

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

To evaluate the safety and reliability of thermal ablation therapy instead of breast-conserving Surgery (BCS), we performed radiofrequency ablation (RFA) for clinical stage I breast cancer patients. Subjects were T1N0 breast cancer patients with no extensive intraductal components. Under general anesthesia, sentinel node biopsy was performed, followed by RFA and BCS. Resected specimens were examined at 5-mm intervals by hematoxylin-eosin (H&E) staining and nicotinamide adenine dinucleotide (NADH) diaphorase staining. Thirty of the 34 eligible patients were enrolled. RFA-related adverse events were observed in nine patients: two with skin burn and seven with muscle burn. Twenty-six patients (87%) showed pathological degenerative changes in tumor specimens with H&E staining. In 24 of the 26 cases (92%) examined by NADH diaphorase staining, tumor cell viability was diagnosed as negative. RFA proved to be reliable and feasible in clinical stage I breast cancer, with no extensive intraductal components. Randomized clinical trials are needed to compare RFA with BCS. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：130 / 134

页数：5

共 23 条

[1]

Abe O, 2005, LANCET, V366, P2087, DOI 10.1016/s0140-6736(05)66544-0

[2] Radiofrequency ablation of invasive breast carcinoma followed by delayed surgical excision [J].

Burak, WE ;

Agnese, DM ;

Povoski, SP ;

Yanssens, TL ;

Bloom, KJ ;

Wakely, PE ;

Spigos, DG .

CANCER, 2003, 98 (07) :1369-1376

[3] Neoadjuvant therapy with paclitaxel followed by 5-fluorouracil, epirubicin, and cyclophosphamide chemotherapy and concurrent trastuzumab in human epidermal growth factor receptor 2-positive operable breast cancer: An update of the initial randomized study population and data of additional patients treated with the same regimen [J].

Buzdar, Aman U. ;

Valero, Vicente ;

Ibrahim, Nuhad K. ;

Francis, Deborah ;

Broglio, Kristine R. ;

Theriault, Richard L. ;

Pusztai, Lajos ;

Green, Marjorie C. ;

Singletary, Sonja E. ;

Hunt, Kelly K. ;

Sahin, Aysegul A. ;

Esteva, Francisco ;

Symmans, William F. ;

Ewer, Michael S. ;

Buchholz, Thomas A. ;

Hortobagyi, Gabriel N. .

CLINICAL CANCER RESEARCH, 2007, 13 (01) :228-233

[4] Laser therapy for small breast cancers [J].

Dowlatshahi, K ;

Francescatti, DS ;

Bloom, KJ .

AMERICAN JOURNAL OF SURGERY, 2002, 184 (04) :359-363

[5] Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer [J].

Fisher, B ;

Anderson, S ;

Bryant, J ;

Margolese, RG ;

Deutsch, M ;

Fisher, ER ;

Jeong, J ;

Wolmark, N .

NEW ENGLAND JOURNAL OF MEDICINE, 2002, 347 (16) :1233-1241

[6] MR imaging-guided focused US ablation of breast cancer: Histopathologic assessment of effectiveness-initial experience [J].

Gianfelice, D ;

Khiat, A ;

Amara, M ;

Belblidia, A ;

Boulanger, Y .

RADIOLOGY, 2003, 227 (03) :849-855

[7] Percutaneous image-guided radiofrequency ablation of painful metastases involving bone:: A multicenter study [J].

Goetz, MP ;

Callstrom, MR ;

Charboneau, JW ;

Farrell, MA ;

Maus, TP ;

Welch, TJ ;

Wong, GY ;

Sloan, JA ;

Novotny, PJ ;

Petersen, IA ;

Beres, RA ;

Regge, D ;

Capanna, R ;

Saker, MB ;

Grönemeyer, DHW ;

Gevargez, A ;

Ahrar, K ;

Choti, MA ;

de Baere, TJ ;

Rubin, J .

JOURNAL OF CLINICAL ONCOLOGY, 2004, 22 (02) :300-306

[8] Treatment of invasive breast carcinoma with ultrasound-guided radiofrequency ablation [J].

Hayashi, AH ;

Silver, SF ;

van der Westhuizen, NG ;

Donald, JC ;

Parker, C ;

Fraser, S ;

Ross, AC ;

Olivotto, IA .

AMERICAN JOURNAL OF SURGERY, 2003, 185 (05) :429-435

[9]

Izzo F, 2001, CANCER, V92, P2036, DOI 10.1002/1097-0142(20011015)92:8<2036::AID-CNCR1542>3.0.CO

[10]

2-W

← 1 2 3 →