Elevated inflammatory proteins in cerebrospinal fluid from patients with painful knee osteoarthritis are associated with reduced symptom severity

被引：20

作者：

Palada, Vinko ^{[1
]}

Ahmed, Aisha Siddiqah ^{[2
]}

Freyhult, Eva ^{[3
]}

Hugo, Anders ^{[4
]}

Kultima, Kim ^{[1
,3
]}

Svensson, Camilla I. ^{[1
]}

Kosek, Eva ^{[2
]}

机构：

[1] Karolinska Inst, Dept Physiol & Pharmacol, S-17177 Stockholm, Sweden

[2] Karolinska Inst, Dept Clin Neurosci, S-17177 Stockholm, Sweden

[3] Uppsala Univ, Dept Med Sci, S-75185 Uppsala, Sweden

[4] Ortho Ctr Stockholm, S-19489 Upplands Vasby, Sweden

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2020年 / 349卷

基金：

瑞典研究理事会;

关键词：

Osteoarthritis (OA); Knee pain; Neuroinflammation; Proximity extension assay (PEA); Cerebrospinal fluid; Serum; Cytokines; Chemokines; BLOOD-BRAIN-BARRIER; MONOCYTE CHEMOATTRACTANT PROTEIN-1; SYNOVIAL-FLUID; MECHANICAL STIMULI; CYTOKINE LEVELS; RECEPTOR; SYSTEM; SENSITIZATION; INTERLEUKIN-8; FIBROMYALGIA;

D O I：

10.1016/j.jneuroim.2020.577391

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Neuroinflammation and periphery-to-CNS neuroimmune cross-talk in patients with painful knee osteoarthritis (OA) are poorly understood. We utilized proximity extension assay to measure the level of 91 inflammatory proteins in CSF and serum from OA patients and controls. The patients had elevated levels of 48 proteins in CSF indicating neuroinflammation. Ten proteins were correlated between CSF and serum and potentially involved in periphery-to-CNS neuroimmune cross-talk. Seven CSF proteins, all with previously reported neuroprotective effects, were associated with lower pain intensity and milder knee-related symptoms. Our findings indicate that neuroinflammation in OA could be protective and associated with less severe symptoms.

引用

页数：11

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